Undecanol, branched and linear

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

migrated information: read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

key study

Study period:

1972

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: The study was conducted according to a protocol that is equivalent to current guideline. Not compliant with GLP. The study was read across from undecan-1-ol (CAS 112-42-5).

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1972

Report date:

1972

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

Observation period was 10 days.

GLP compliance:

not specified

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Undecan-1-ol

EC Number:

203-970-5

EC Name:

Undecan-1-ol

Cas Number:

112-42-5

Molecular formula:

C11H24O

IUPAC Name:

undecan-1-ol

Details on test material:

No detail available.

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male

Details on test animals or test system and environmental conditions:

Average temperature inside chamber: 78F
Average relative humidity inside chamber: 80%

Administration / exposure

Route of administration:

inhalation: vapour

Type of inhalation exposure:

whole body

Vehicle:

other: air

Details on inhalation exposure:

The rats were placed in a stainless steel chamber of 35 litres capacity and exposed to a concentrated atmosphere of vapours produced by passing a stream of air through 130.5 grams of the compound contained in a 300 milliliter flask. The sample was maintained at a temperature of 100C by immersing flask in heated sand bath. Vapours from the flask passed into one litre bottle to remove droplets and then into the chamber. Air flow through tthe sample was 4.0 litres per minute as measured by a calibrated rotameter. This was sufficient to violently agitate the liquid. No supplementary air was introduced inasmuch as the above supply was ample for the animals oxygen requirements.

Analytical verification of test atmosphere concentrations:

not specified

Duration of exposure:

6 h

Concentrations:

0.4 mg/l

No. of animals per sex per dose:

6

Control animals:

not specified

Details on study design:

The animals were observed for behaviour during exposure and for ten days following exposure. The viscera of the animals were examined macroscopically.

Results and discussion

Effect levels

Sex:

male

Dose descriptor:

LC50

Effect level:

> 700 mg/m³ air

Exp. duration:

6 h

Mortality:

There were no deaths during the exposure or the 10 days observation period.

Clinical signs:

other: Upon removal from the chambre the fur was roughened; respiration was normal and no other signs of toxic distress were noted.The ten day observation period was uneventful.

Body weight:

The weight gain was normal.

Gross pathology:

The viscera appeared normal by macroscopic examination.

Applicant's summary and conclusion

Interpretation of results:

practically nontoxic

Remarks:

Migrated information Criteria used for interpretation of results: not specified

Conclusions:

Rat 6 hour LC50 was reported to be >700mg/m3 air. The study was equivalent to guideline. The result was read across from undecan-1-ol (CAS 112-42-5).