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REACH

Copper hydroxide nitrate (Cu2(OH)3(NO3))

EC number: 439-590-3 | CAS number: 12158-75-7

Life Cycle description
Uses advised against

Toxicological information

Endpoint summary

Administrative data

Key value for chemical safety assessment

Additional information

Ames test (OECD 471) was carried out on Basic Copper Nitrate. Under the conditions of the study, Basic Copper Nitrate did not induce a significant dose-related increase in the number of revertant (His+) colonies in each of the four tester strains (TA1535, TA1537, TA98 and TA100) and in the number of revertant (Trp+) colonies in tester strain WP2uvrA both in the absence and presence of S9-metabolic activation. These results were confirmed in an independently repeated experiment.

A micronucleus test with mice (OECD 474) was also conducted. The results obtained in this study and under the test conditions described Copper Hydroxide Nitrate did not produce relevant increases of the numbers of micronuclei in polychromatic erythrocytes in animals of either sex of the test species at doses of 300, 600 or 900mg Copper Hydroxide Nitrate per Kg body mass and sampling times of 24 and 48 hours p.a. The bioavailability of the test substance was proven by mortality and marked cytotoxicity at the high dose.

Short description of key information:
- Reverse mutation assay study in bacteria - Notox, 2010
- Micronucleus test with mice - TIB Goldschmidt, 2004

Endpoint Conclusion: No adverse effect observed (negative)

Justification for classification or non-classification

Based on the outcomes of the studies carried out, Basic Copper Nitrate does not meet the criteria for classification under Regulation EC 1272/2008.

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