Registration Dossier
Registration Dossier
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EC number: 800-526-8 | CAS number: 1273322-45-4
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Data on toxicokinetics of the submission substance are not available. Default values based on physico-chemical information according to REACH Guidance are therefore used for the estimation of the kinetic profile. Based on the molecular mass of approximately 300 and a log Kow of 2.8 a default value of 100% is used for oral as well as for dermal absorption. Respiratory absorption, however, is considered to be negligible because the material is a solid wax with a very low vapour pressure and a moderate water solubility.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
- Absorption rate - oral (%):
- 100
- Absorption rate - dermal (%):
- 100
Additional information
The toxicokinetic profile of a substance comprises its absorption into the body, its distribution in the body, its metabolism in the body and its excretion from the body. Experimental data on toxicokinetics for the registration substance is not available. However, taking into account the physicochemical properties of the registration substance, qualitative estimates for these aspects may be deduced for the submission substance.
A prerequisite for a relevant absorption is that the substance can be dissolved in either aqueous (e.g., gastrointestinal fluid, blood plasma, sweat) or lipophilic (e.g., lipoproteins, lipid membranes, triglycerides) media or in both. The submission substance is moderatly soluble in water and good soluble in n-octanol, leading to a log Kow of 2.8. This relative solubility is favourable for absorption via the gastrointestinal tract following oral exposure as well as regarding dermal absorption. In the absence of substance specific data and according to ECHA Guidance R.7c, a default value of 100% for oral and skin absorption therefore apply for risk characterization purposes. Due to this physico-chemical profile, metabolism and excretion of the submission substance can be expected and thus a bioaccumulation potential can most probably be excluded. The likelihood for inhalation exposure is low due to the very low vapour pressure of the test item. Additionally, since the submission substance is a solid wax, formation of inhalable/respirable aerosols and thus absorption via the inhalation route is unlikely.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
