Registration Dossier
Registration Dossier
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EC number: 219-553-6 | CAS number: 2461-15-6
Hydrolysis
Administrative data
- Endpoint:
- hydrolysis
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 2008
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Hydrolysis data is available from the US EPA report for n-Butyl Glycidyl Ether (CAS No. 2426-08-6), which is structurally similar to 2-Ethylhexyl glycidyl ether (EC# 219-553-6). Thus the study is used for read-across to avoid duplicate tests.
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 2 008
Materials and methods
- Principles of method if other than guideline:
- not specified
- GLP compliance:
- no
Test material
- Reference substance name:
- Butyl 2,3-epoxypropyl ether
- EC Number:
- 219-376-4
- EC Name:
- Butyl 2,3-epoxypropyl ether
- Cas Number:
- 2426-08-6
- Molecular formula:
- C7H14O2
- IUPAC Name:
- 2-(butoxymethyl)oxirane
- Reference substance name:
- n-Butyl glycidyl ether
- IUPAC Name:
- n-Butyl glycidyl ether
- Test material form:
- other: liquid
- Details on test material:
- Melting Point: -30.96 °C (measured)
Boiling Point: 164 °C (measured)
Vapor Pressure: 3.2 mm Hg at 25 °C (measured)
Water Solubility: 20,000 mg/L at 20 °C (measured)
Constituent 1
Constituent 2
- Radiolabelling:
- not specified
Study design
- Analytical monitoring:
- not specified
- Positive controls:
- not specified
- Negative controls:
- not specified
Results and discussion
- Transformation products:
- not specified
Dissipation DT50 of parent compoundopen allclose all
- pH:
- 4
- Temp.:
- 20 °C
- DT50:
- 0.3 h
- pH:
- 7
- Temp.:
- 20 °C
- DT50:
- 20 d
- pH:
- 9
- Remarks on result:
- other: stable
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- Hydrolysis half-life: 0.3 hours at pH 4 (20 °C), 20 days at pH 7 (20 °C), stable at pH 9
- Executive summary:
Based on the results of n-Butyl Glycidyl Ether (CAS No. 2426-08-6), the hydrolysis half-life values were 0.3 hours at pH 4 (20 °C), 20 days at pH 7 (20 °C), stable at pH 9. 2-Ethylhexyl glycidyl ether (EC# 219-553-6) has the similar property, which can be consider with the same half-life values. These values indicate the hydrolysis rate of 2-Ethylhexyl glycidyl ether is rapid under acidic conditions and moderate to slow at neutral and alkaline pH.
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