Registration Dossier
Registration Dossier
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EC number: 203-328-4 | CAS number: 105-76-0
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
Daphnia magna EC50 (48 hrs): 21 mg/l (static, nominal values)
Daphnia magna EC50 (24 hrs) 15 mg/l and 139 mg/l (both static and nominal values)
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 21 mg/L
Additional information
Three studies are available for dibutylmaleate, all assessing the effects of the substance to the freshwater invertebrate Daphnia magna. One study was conducted according to OECD 202, reporting an EC50 of 21 mg/l. An analytical determination of the test substance concentration was conducted, indicating a sufficient stability of dibutyl maleate over the test period of 48 hours. The EC50 value could therefore be referred to nominal values. Two 24-hour studies were conducted using the German national standard DIN 38412 method and reported 24-h EC50 values of 15 and 139 mg/L, respectively. Both endpoints were referred to nominal values as no analytical measurement of the test substance concentrations was conducted. Due to the fact that the exposure periods of the studies were only 24 hours and due to the lack of analytical information, they are regarded as supporting information. Therefore, the EC50 value derived from the OECD study was selected as the key parameter although a lower EC50 was reported in one of the 24-hour tests.
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