Registration Dossier
Registration Dossier
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EC number: 260-354-9 | CAS number: 56718-71-9
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- 6 animals/dose group. Doses given were 1000, 1300, 1600, 2000, 2500 mg/kg.
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- p-(2-methoxyethyl)phenol
- EC Number:
- 260-354-9
- EC Name:
- p-(2-methoxyethyl)phenol
- Cas Number:
- 56718-71-9
- Molecular formula:
- C9H12O2
- IUPAC Name:
- 4-(2-methoxyethyl)phenol
- Test material form:
- other: crystals to viscous liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- polyethylene glycol
- Doses:
- 1000, 1300, 1600, 2000, 2500 mg/kg
- No. of animals per sex per dose:
- 6
- Control animals:
- yes
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- other: mortality
- Effect level:
- 2 500 mg/kg bw
- Mortality:
- One mortality at 2500 mg/kg, within 24 hours of dosing.
- Clinical signs:
- other: Sedation and lacrimation, within half an hour of administration in the 3 highest dose groups.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- LD50 > 2000 mg/kg
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