Registration Dossier
Registration Dossier
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EC number: 701-005-7 | CAS number: -
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- publication
- Title:
- Acute toxicity of a homologous series of branched chain primary alcohols
- Author:
- Scala, R., Burtis E.
- Year:
- 1 973
- Bibliographic source:
- Am. Ind. Hyg. Assoc. J. 34: 493-499
Materials and methods
- Principles of method if other than guideline:
- The principle of method was similar to guideline-study.
- Test type:
- standard acute method
Test material
- Reference substance name:
- Alcohols, C11-14-iso-, C13-rich
- EC Number:
- 271-235-6
- EC Name:
- Alcohols, C11-14-iso-, C13-rich
- Cas Number:
- 68526-86-3
- Molecular formula:
- Unspecified
- IUPAC Name:
- Alcohols, C11-14-iso-, C13-rich
- Details on test material:
- C11‑C14-iso, C13 rich (CAS RN 68526-86-3)
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: Albino
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- occlusive
- Details on dermal exposure:
- The alcohol was applied full-strength to the closely clipped, intact abdominal skin. The exposed area was covered with an occlusive binding of dental damming for 24 hours. After the exposure, the binding was removed, and the remaining material, if any, was cleanded from the skin. The animals were housed individually with feed and water freely available. No mechanical restraints were used..
- Duration of exposure:
- 24 hours
- Doses:
- 0.1, 0.316, 1.00, and 3.16 ml/kg were administered volumetrically.
- No. of animals per sex per dose:
- 4
- Details on study design:
- The animals were given a single application of the test substance to abraded abdominal skin under occlusive dressing for 24 hours.
Observations for dermal irritation were made on a daily basis. Gross necropsies were performed at the end of the experiments.
Results and discussion
Effect levels
- Dose descriptor:
- LD50
- Effect level:
- > 2 600 mg/kg bw
- Mortality:
- No deaths were reported.
Applicant's summary and conclusion
- Conclusions:
- Scala and Burtis (1973) reported dermal LD50 values in rabbits of > 2600 mg/kg for alcohols C11‑C14-iso, C13 rich (CAS RN 68526-86-3).
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