Registration Dossier
Registration Dossier
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EC number: 600-786-0 | CAS number: 106904-09-0
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study according EU/OECD guideline.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 008
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 tris (Acute Oral Toxicity - Acute Toxic Class Method)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
Test material
- Reference substance name:
- 2-chloro-4-methanesulfonyl-3-methylbenzoic acid
- EC Number:
- 600-786-0
- Cas Number:
- 106904-09-0
- Molecular formula:
- C9H9ClO4S
- IUPAC Name:
- 2-chloro-4-methanesulfonyl-3-methylbenzoic acid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: tap water with 2% Cremophor EL
- Doses:
- 2000 mg/kg body weight (bw)
- No. of animals per sex per dose:
- 3 female rats
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- >= 5 000 mg/kg bw
- Remarks on result:
- other: Category 5 / unclassified of the Globally Harmonized Classification System
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category V
- Remarks:
- Migrated information Criteria used for interpretation of results: other: EU and OECD GHS
- Executive summary:
According to OECD guideline 423 the LD50 cut-off of the test substance is >= 5000 mg/kg bw. (Category 5 / unclassified of the Globally Harmonized Classification System).
A dose of 2000 mg/kg body weight was tolerated by female rats without mortalities, clinical signs, effects on weight gain and gross pathological findings
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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