Registration Dossier
Registration Dossier
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EC number: 203-402-6 | CAS number: 106-48-9
Toxicity to microorganisms
Administrative data
- Endpoint:
- toxicity to microorganisms
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well documented publication which meets basic scientific principles.
Data source
Reference
- Reference Type:
- publication
- Title:
- A database of chemical toxicity to environmental bacteria and its use in interspecies comparisons and correlations.
- Author:
- Blum, D.J.W. and Speece, R.E.
- Year:
- 1 991
- Bibliographic source:
- Research Journal WPCF 3: 198-207
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- 96h anaerobic toxicity assay with methanogen bacteria; 49h toxicity test with activated sludge; 24h nitrification inhibition test and Microtox biassay with Photobacterium phosphoreum
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 4-chlorophenol
- EC Number:
- 203-402-6
- EC Name:
- 4-chlorophenol
- Cas Number:
- 106-48-9
- Molecular formula:
- C6H5ClO
- IUPAC Name:
- 4-chlorophenol
- Details on test material:
- - Name of test material (as cited in study report): 4-chlorophenol
- Analytical purity: not stated
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
Test solutions
- Vehicle:
- no
Test organisms
- Test organisms (species):
- other: methanogens; activated sludge; Nitrosomonas; Photobacterium phosphoreum
Study design
- Test type:
- not specified
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 5
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 96 h
- Dose descriptor:
- IC50
- Effect conc.:
- 270 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- not specified
- Basis for effect:
- other: inhibition of gas production
- Remarks on result:
- other: methanogens
- Duration:
- 49 h
- Dose descriptor:
- IC50
- Effect conc.:
- 98 mg/L
- Nominal / measured:
- not specified
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Remarks:
- respiration rate
- Remarks on result:
- other: activated sludge
- Duration:
- 24 h
- Dose descriptor:
- IC50
- Effect conc.:
- 0.73 mg/L
- Nominal / measured:
- not specified
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of nitrification rate
- Remarks on result:
- other: Nitrosomonas
- Duration:
- 5 min
- Dose descriptor:
- IC50
- Effect conc.:
- 0.95 mg/L
- Nominal / measured:
- not specified
- Conc. based on:
- test mat.
- Basis for effect:
- other: inhibition of bioluminescence
- Remarks on result:
- other: Microtox test
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
