Registration Dossier

Administrative data

Endpoint:
nanomaterial Zeta potential
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Study with accepted scientific standards

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
2010
Report date:
2010

Materials and methods

Test guideline
Guideline:
other: measured
Principles of method if other than guideline:
The particles were separated by electrophoresis and analyzed by a laser Doppler vibrometer.
GLP compliance:
no
Type of method:
electrophoresis
Details on methods and data evaluation:
The zeta-potential of Tinosorb A2B was measured at different pH values using a Malvern Zeta-
Sizer device.

Test material

Constituent 1
Test material form:
solid: nanoform

Data gathering

Instruments:
The Zeta-potential of Tinosorb A2B was measured at different pH values using a Malvern Zeta-
Sizer device.

Results and discussion

Zeta potentialopen allclose all
Zeta potential:
ca. -3 mV
pH:
2.5
Medium:
Water
Zeta potential:
ca. -30 mV
pH:
4
Medium:
water

Any other information on results incl. tables

At realistic pH values (pH 6 – pH 8) the zeta-potential of Tinosorb A2B is quite negative.

However, in these realistic environments salts are likely to be present and the potential will

be damped to lower values. Overall, the Tinosorb A2B particles in formulation will be

expected to show a negative zeta potential.

Applicant's summary and conclusion

Conclusions:
At realistic pH values (pH 6 – pH 8) the zeta-potential of Tinosorb A2B is quite negative.
However, in these realistic environments salts are likely to be present and the potential will
be damped to lower values. Overall, the Tinosorb A2B particles in formulation will be
expected to show a negative zeta potential.