Registration Dossier
Registration Dossier
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EC number: 601-431-2 | CAS number: 1164-92-7
Hydrolysis
Administrative data
- Endpoint:
- hydrolysis
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- other information
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 000
- Report date:
- 2000
Materials and methods
Results and discussion
Dissipation DT50 of parent compoundopen allclose all
- pH:
- 4
- Temp.:
- 25 °C
- DT50:
- > 1 yr
- Remarks on result:
- other: estimation
- pH:
- 7
- Temp.:
- 25 °C
- DT50:
- > 1 yr
- Remarks on result:
- other: estimation
- pH:
- 9
- Temp.:
- 25 °C
- DT50:
- ca. 27 d
- Remarks on result:
- other: estimation
Any other information on results incl. tables
Test substance (ZK 5180) |
17 beta-Acetoxy-5alpha-androstan-3-one |
||
Analogous compound (ZK 5777)
|
17 beta-Acetoxy-5 alpha-androst-1-en-3-one |
||
Kinetic data for hydrolysis of ZK 5777at 25°C (Schering report MR27) |
pH |
rate constant k [h–1] (or statement) |
half-life, t1/2 |
|
4 7 9 |
stable stable 1.070 · 10-3 |
> 1 year > 1 year 27 days |
|
“Stable” signifies that less than 10 % of the test substance were degraded at the respective pH value during 5 days at 50 °C, corresponding to a half-life > 1 year at 25 °C. |
||
Applicant's summary and conclusion
- Executive summary:
The only hydrolyzable functional group in androstanolon-acetat is the ester function in position17. The hydrolytic behaviour is expected to be similar to that of the structurally closely related compound delta 1- androstenolen-acetat , which differs in an additional double bond in ring A of the steroid moiety, only.
The rate of hydrolysis of this compound was determined according to EC guideline C.7 at pH 4, 7 and 9. The compound was found to be hydrolytically stable at pH 4 and pH 7 at 25 °C. The half-lives at pH 9, 25 °C was 27 days.
Comparable results are to be expected for androstanolon-acetat.
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