Registration Dossier
Registration Dossier
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EC number: 203-742-5 | CAS number: 110-16-7
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: data from OECD SIDS draft maleic acid
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- Maleic Anhydride Toxicity and Health Summary
- Author:
- Eastman Kodak Company
- Year:
- 1 969
- Bibliographic source:
- Unpublished data from the Laboratory of Industrial Medicine, Eastman Kodak Company, Rochester, N.Y. Submitted to US EPA by Eastman Kodak Company as EPA Doc. No. 878214722; cited in OECD SIDS Draft Maleic Acid (2005)
- Reference Type:
- secondary source
- Title:
- Dangerous Properties of Industrial Materials
- Author:
- Sax, N. I. & Lewis, R.J.Sr.
- Year:
- 1 989
- Bibliographic source:
- Seventh edition. Vol III. Van Nostrand Reinhold, New York, U.S.A. #MAK609, p.2155; cited in OECD SIDS Draft Maleic Acid (2005)
Materials and methods
- Principles of method if other than guideline:
- Comparable to Draize test conditions; however, information on animal number occlusive conditions are missing
- GLP compliance:
- no
Test material
- Reference substance name:
- Maleic acid
- EC Number:
- 203-742-5
- EC Name:
- Maleic acid
- Cas Number:
- 110-16-7
- Molecular formula:
- C4H4O4
- IUPAC Name:
- but-2-enedioic acid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- not specified
- Vehicle:
- not specified
- Controls:
- not specified
- Amount / concentration applied:
- 500 mg
- Duration of treatment / exposure:
- 24 h
- Observation period:
- no data
- Number of animals:
- no data
Results and discussion
In vivo
Results
- Irritation parameter:
- other: irritation
- Basis:
- mean
- Time point:
- other: 24/48/72 hours
- Score:
- > 0
- Remarks on result:
- other: Application of 500 mg maleic acid for 24 hours produced mild skin irritation in the rabbit
Any other information on results incl. tables
Application of 500 mg maleic acid for 24 hours produced mild skin irritation in the rabbit
Applicant's summary and conclusion
- Interpretation of results:
- irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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