Registration Dossier

Administrative data

Endpoint:
bioaccumulation: aquatic / sediment
Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:
other:

Data source

Reference
Reference Type:
other: Phd Thesis
Title:
Bioconcentration of surfactants
Author:
J. Tolls
Year:
1998
Bibliographic source:
ISBN No.: 90-393-1676-1, Utrecht University

Materials and methods

Results and discussion

Applicant's summary and conclusion

Conclusions:
The aquatic bioaccumulation is scientifically unjustified. The octanol-water coefficient has been measured according to OECD 107 resulting in a Log Pow of 3.3 (see 4.7 Partition coefficient). Although the Log Pow is a suitable indicator for a screening assessment of bioaccumulation it is well accepted that the meaning of measured Log Pow for surfactants is meaningless.
Toll et al. studied the bioaccumulation of different anionic and non-ionic surfactants. He could show, that the hydrophobic parts of LAS (= Linear Alkylbenzolsulfonate) and Fatty alcohol ethoxylates were readliy biotransformed in vivo. The prediction of the bioaccumulation potential due to the Log Pow was therefore considered to be not realistic and misleading. Fatty acid salts are main constituents of organic material and ubiquitos in the organism. As such they are biotransformed via ß-oxidation. Hence a bioaccumulation potential of fatty acid C16-18, sodium salt is considered very low.
Executive summary:

The aquatic bioaccumulation is scientifically unjustified. The octanol-water coefficient has been measured according to OECD 107 resulting in a Log Pow of 3.3 (see 4.7 Partition coefficient). Although the Log Pow is a suitable indicator for a screening assessment of bioaccumulation it is well accepted that the meaning of measured Log Pow for surfactants is meaningless. Toll et al. studied the bioaccumulation of different anionic and non-ionic surfactants. He could show, that the hydrophobic parts of LAS (= Linear Alkylbenzolsulfonate) and Fatty alcohol ethoxylates were readliy biotransformed in vivo. The prediction of the bioaccumulation potential due to the Log Pow was therefore considered to be not realistic and misleading. Fatty acid salts are main constituents of organic material and ubiquitos in the organism. As such they are biotransformed via ß-oxidation. Hence a bioaccumulation potential of fatty acid C16-18, sodium salt is considered very low.