Registration Dossier
Registration Dossier
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EC number: 204-468-9 | CAS number: 121-43-7
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- short-term repeated dose toxicity: oral
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Meets generally accepted scientific standards, sufficiently documented.
Data source
Reference
- Reference Type:
- publication
- Title:
- Biochemical changes in brain in methanol poisoning--an experimental study.
- Author:
- Rao, K.R. et al.
- Year:
- 1 977
- Bibliographic source:
- Indian J Med Res 65(2): 285-292
Materials and methods
- Principles of method if other than guideline:
- Daily application of a single dose of methanol to monkeys by gavage over a period of 3 days.
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- Methanol
- EC Number:
- 200-659-6
- EC Name:
- Methanol
- Cas Number:
- 67-56-1
- Molecular formula:
- CH4O
- IUPAC Name:
- methanol
- Details on test material:
- - Name of test material (as cited in study report): methanol
- Analytical purity: no data
Constituent 1
Test animals
- Species:
- monkey
- Strain:
- not specified
- Sex:
- male
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 30 % solution
- Amount of vehicle (if gavage): no data - Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 3 days
- Frequency of treatment:
- daily
Doses / concentrations
- Remarks:
- Doses / Concentrations:
2340 mg/kg bw
Basis:
actual ingested
- No. of animals per sex per dose:
- 7 males
- Control animals:
- not specified
Results and discussion
Effect levels
- Dose descriptor:
- LOAEL
- Effect level:
- 2 340 mg/kg bw/day (actual dose received)
- Sex:
- male
- Basis for effect level:
- other: mortality
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
2340 mg/kg bw was the lethal dose for all 7 animals under test after 3 days.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
