Registration Dossier
Registration Dossier
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EC number: 201-116-6 | CAS number: 78-42-2
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: No OECD guideline or GLP defined, insufficient and very limited data documentation.
Data source
Reference
- Reference Type:
- other: Microfiche
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1944
Materials and methods
- Principles of method if other than guideline:
- acute dam test of toxicity by skin penetration in rabbits
- GLP compliance:
- not specified
- Test type:
- other: acute dam test of toxicity by skin penetration in rabbits
- Limit test:
- yes
Test material
- Reference substance name:
- Tris(2-ethylhexyl) phosphate
- EC Number:
- 201-116-6
- EC Name:
- Tris(2-ethylhexyl) phosphate
- Cas Number:
- 78-42-2
- Molecular formula:
- C24H51O4P
- IUPAC Name:
- tris(2-ethylhexyl) phosphate
- Details on test material:
- Test samples:
7-45 Victor Chemical via Bound Brook, received 4-26-44
8-52 Victor Chemical via Bound Brook, received 2-21-45
8-74 Carbide D-764-67-2 via Bound Brook, received 5-21-45
8-80 Carbide 142-RD-99 distilled via Bound Brook, received 6-13-45
8-81 Carbide 142-RD-91 via Bound Brook, received 6-13-45
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Duration of exposure:
- no data
- Doses:
- 20 ml/kg bw.
- No. of animals per sex per dose:
- see: executive summary
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- other: no data
- Remarks on result:
- other: In this very limited documented test in female rabbits in which different tris(2-ethylhexyl)phosphate test materials (purities not given) were tested at 20 ml/kg bw. (approx 19000 mg/kg), mortality was observed with all 4 samples; 7/10, 5/10, 2/5 and 2/4
Any other information on results incl. tables
Mortality was observed with all 4 samples; 7/10, 5/10, 2/5 and 2/4 respectively.
Applicant's summary and conclusion
- Executive summary:
A very limited documented acute dermal toxicity test in female rabbits is available in which different tris(2-ethylhexyl)phosphate test materials (purities not given) were tested at 20 ml/kg bw. Mortality was observed with all 4 samples; 7/10, 5/10, 2/5 and 2/4 respectively.
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