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EC number: 278-770-4 | CAS number: 77804-81-0
Based on the available data base on C.I. Pigment Yellow 180 relevant information exists to make a qualitative evaluation of the toxicokinetic profile of this compound. This is in line with animal welfare considerations because additional animal tests can be avoided by such an evaluation. The substance is available in non-nano- as well as nano-form. The available data have been generated with non-nano material, but the conclusions drawn are considered valid for the nano form as well, because the material is chemically identical and the physical properties are widely overlapping.
The results of basic toxicity testing give no reason to anticipate unusual characteristics regarding the toxicokinetics of C.I. Pigment Yellow 180. The data indicate that there is no relevant dermal absorption. C.I. Pigment Yellow 180 is not absorbed from the gastro-intestinal tract in toxicologically significant amounts. Indications of a bio-accumulative potential as well as metabolism towards genotoxic sub-structures do not exist. Excretion of small amounts of possibly systemically available C.I. Pigment Yellow 180 and/or metabolites via faeces is likely.
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