Registration Dossier
Registration Dossier
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EC number: 215-233-5 | CAS number: 1314-36-9
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
No data is available on yttrium oxide but this substance is closed to cerium oxide regarding the physico-chemical, toxicological and ecotoxicological properties. Indeed, both substances are high melting point solids (form: powder) of low water solubility and they does not present any classification regarding health and environmental hazards.
By comparison and according to the read across strategy proposed, the yttrium oxide is not expected to present toxicity to aquatic algae.
Read across is trust possible from cerium oxide for which an aquatic algae study was conducted and showed that the substance had no toxic effect on survival and reproduction of Daphnia magna after the exposure period of 22 days up to the loading rate of 100 mg/L.
Thus, the NOELR of the test item was determined to be at least the loading rate of 100 mg/L . The LOELR was above the loading rate of 100 mg/L.
Key value for chemical safety assessment
Additional information
One GLP-compliant study is available on cerium oxide It is quoted as reliability 1 according to Klimisch criteria, flagged as a key study and it reveals that the substance is not toxic to algae at or above 100 mg/L.
A statistically significant inhibitory effects was reported on the growth of Scenedesmus subspicatus after the test period of 72 h first at the maximum loading rate. However a significant phosphate depletion was observed at the highest tested concentration, probably due to a complexation process with the test item. As a consequence, the reduction of growth here observed was probably caused by an indirect effect of phosphate lack, rather than a toxic effect of cerium dioxide.
By comparison and according to the read across strategy proposed in the "toxicity to aquatic algae and cyanobacteria", the yttrium oxide is not expected to present toxicity to aquatic algae.
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