Registration Dossier
Registration Dossier
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EC number: 207-586-9 | CAS number: 482-89-3
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1972
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: BASF internal guideline followed
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 972
- Report date:
- 1972
Materials and methods
- Principles of method if other than guideline:
- BASF-Testing method
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-(1,3-dihydro-3-oxo-2H-indol-2-ylidene)-1,2-dihydro-3H-indol-3-one
- EC Number:
- 207-586-9
- EC Name:
- 2-(1,3-dihydro-3-oxo-2H-indol-2-ylidene)-1,2-dihydro-3H-indol-3-one
- Cas Number:
- 482-89-3
- Molecular formula:
- C16H10N2O2
- IUPAC Name:
- 2-(1,3-dihydro-3-oxo-2H-indol-2-ylidene)-1,2-dihydro-3H-indol-3-one
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- - Name of test material (as cited in study report): Handelsware Indigo rein BASF Pulver
- Substance type: active ingredient
- Physical state: solid
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- CMC (carboxymethyl cellulose)
- Details on exposure:
- 2% to 30% concentration in vehicle
- Doses:
- no data
- No. of animals per sex per dose:
- no data
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 7 days
- Frequency of observations and weighing: no data
- Necropsy of survivors performed: yes - Statistics:
- NA
Results and discussion
Effect levels
- Dose descriptor:
- LD50
- Effect level:
- ca. 8 000 mg/kg bw
- Mortality:
- no data
- Clinical signs:
- ataxia, dyspnea, blue discoloration of fur
- Body weight:
- no data
- Gross pathology:
- discoloration of organs, intraabdominal precipitation of TS, blunt liver margins, enlarged spleen
Applicant's summary and conclusion
- Conclusions:
- The intraperitoneal LD50 in the mouse is approximately 8000 mg/kg bw
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