Registration Dossier
Registration Dossier
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EC number: 932-121-8 | CAS number: 1147459-12-8
Endpoint summary
Administrative data
Description of key information
Additional information
No short-term terrestrial test data is available for N-[3-(dimethylamino)propyl]-C12-18(even numbered)-alkylamide. But one long-term earthworm test has been performed with Amides, C18-unsatd., N-[3-(dimethylamine)propyl].
Eisenia fetida were exposed to the test substance according to OECD Guideline 222 and GLP requirements. All study validity criteria were met. No mortality was observed in any treatment group. The body weight change of the earthworms after 4 weeks exposure was not statistically significant different compared to the control up to and including the highest test concentration of 1000 mg test item/kg soil dw (Dunnett's test,α = 0.05) corresponding to 910 mg a.i./kg soil dw. The reproduction rates after 8 weeks exposure to Amides, C18-unsatd., N-[3-(dimethylamine)propyl] were not significantly different compared to the control up to and including the highest test concentration of 1000 mg test item/kg soil ( Dunnett's t-test,α = 0.05). No behavioural abnormalities were observed in any of the treatment groups.
It is considered justified to use this test result as obtained for Amides, C18-unsatd., N-[3-(dimethylamine)propyl] for read-across to N-[3-(dimethylamino)propyl]-C12-18(even numbered)-alkylamide because a similar toxicity is anticipated for organisms living in the terrestrial compartments. Indeed, the main exposure route for sorbing substances is via ingestion (comber 2008) and the limited expected difference in sorption to soil for a certain soil type because the main driver in the sorption of such substances is ionic interaction.
There are no other data available for characterizing the effects of N-[3-(dimethylamino)propyl]-C12-18(even numbered)-alkylamide
on soil organisms. The substance sorbs strongly to soil and is readily biodegradable. In addition, the test substance was observed to be not harmful to sludge micro-organisms. Further tests on soil micro-organisms do therefore not need to be conducted as no concern is indicated for the terrestrial compartment based on one long-term test result.Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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