Registration Dossier
Registration Dossier
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EC number: 295-835-2 | CAS number: 92129-33-4
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
Toxicity figure based on river water testing.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 3.1 mg/L
Marine water invertebrates
Marine water invertebrates
- Effect concentration:
- 3.3 mg/L
Additional information
The key value used for the chemical safety assessment comes from Lewis and Wee (1983) cited in the EU Risk Assessment DODMAC (2002). The test substance was found to be toxic to invertebrates.
The acute toxicity of DSDMAC to Daphnia magna was assessed for reconstituted and river water with the US EPA test method. After 48 hours, EC50-values of 0.16 mg/L were derived for reconstituted water and 3.1 mg/L for river water (nominal levels of the active ingredient).
The acute toxicity of Quaternary ammonium compounds, di-C16 -18 (even numbered) - alkyldimethyl, chlorides was also evaluated with marine invertebrate, the copepod Acartia tonsa, in a static test over 48 hours in accordance with the draf method ISO 14669:1999(E). LC50 -48h was calculated to be 3.3 mg/L (nominal values).
An investigation into the acute toxicity of DHTDMAC to Daphnia magna was performed according to OECD guideline No 202 and EEC Directive 67/548/EEC Annex V C.2 by Handley and Wetton in 1990. The EC50 was determined to be 1.4 and 0.68 mg/L at 24 and 48 h respectively. The 'no effect' level at 24 h and 48 h were 0.56 mg/L and 0.32 mg/L respectively. The same authors carried out the same test with the same substance but with different purity and the EC50 value was calculated as 0.77 and 0.45 mg/L at 24 and 48 hours respectively. The 'no effect' level at 24 h and 48 h was determined to be 0.56 mg/L (0.44 mg ai/L) and 0.18 mg/L (0.14 mg ai/L).
Boutonnet and Moncel in 1990 observed 100% immobilisation at both 24 and 48 hours at a concentration of 5 mg/L. The maximum concentration at which no effects (NOEC) were observed was <0.1 mg/L for both 24 and 48 hours. The LC50 was estimated to be between 1 and 5 mg/L and 0.63 mg/L at 48 hours.
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