(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoic acid

Genetic toxicity: in vivo

Administrative data

Endpoint:

in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus

Remarks:

Type of genotoxicity: chromosome aberration

Adequacy of study:

other information

Data source

Reference

Reference Type:

other: Body responsible for the test

Title:

Unnamed

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: 84/448/EWG, B.12

GLP compliance:

yes

Type of assay:

micronucleus assay

Test animals

Species:

other: mus, Hoe:NMRKf (SPF 71)

Administration / exposure

Route of administration:

oral: unspecified

Vehicle:

Sesamöl

"ENGLISH"

sesame oil

No. of animals per sex per dose:

Male: 0 mg/kg; No. of animals: 5; Sacrifice time: 24 hours
Male: 0 mg/kg; No. of animals: 5; Sacrifice time: 48 hours
Male: 0 mg/kg; No. of animals: 5; Sacrifice time: 72 hours
Male: 3500 mg/kg; No. of animals: 5; Sacrifice time: 24 hours
Male: 3500 mg/kg; No. of animals: 5; Sacrifice time: 48 hours
Male: 3500 mg/kg; No. of animals: 5; Sacrifice time: 72 hours
Female: 0 mg/kg; No. of animals: 5; Sacrifice times: 24 hours
Female: 0 mg/kg; No. of animals: 5; Sacrifice times: 48 hours
Female: 0 mg/kg; No. of animals: 5; Sacrifice times: 72 hours
Female: 3500 mg/kg; No. of animals: 5; Sacrifice times: 24 hours
Female: 3500 mg/kg; No. of animals: 5; Sacrifice times: 48 hours
Female: 3500 mg/kg; No. of animals: 5; Sacrifice times: 72 hours

Results and discussion

Test results

Toxicity:

yes

Remarks:

Doses producing toxicity: > 3500 mg/kg

Applicant's summary and conclusion

Conclusions:

Interpretation of results (migrated information): negative