[(methylethylene)bis(oxy)]dipropanol

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Study predates OECD guidelines and GLP, minor restrictions in design and reporting, but otherwise adequate for assessment.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1974

Report date:

1974

Materials and methods

Principles of method if other than guideline:

Rats were exposed to saturated vapor of tripropylene glycol generated at room temperature for 8 h.

GLP compliance:

no

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

[(methylethylene)bis(oxy)]dipropanol

EC Number:

246-466-0

EC Name:

[(methylethylene)bis(oxy)]dipropanol

Cas Number:

24800-44-0

Molecular formula:

C9H20O4

IUPAC Name:

1,1'-[propane-1,2-diylbis(oxy)]dipropan-1-ol

Details on test material:

- Name of test material (as cited in study report): Tripropylene glycol
- Substance type: organic
- Analytical purity: not specified
- Lot/batch No.: 06827
- Identification: S-145541
- CHF sample No: 37-61
- Date of receipt: 2-8-74

Test animals

Species:

rat

Strain:

not specified

Sex:

not specified

Details on test animals or test system and environmental conditions:

The nonfasted animals were maintained on appropriate Rockland diets and water ad libitum except during period of manipulation or confinement.

Administration / exposure

Route of administration:

inhalation: vapour

Type of inhalation exposure:

whole body

Vehicle:

other: air

Details on inhalation exposure:

Concentrated vapor was generated in a gas washing bottle by passing dried air at 2.5 l/min through a fritted glass disc immersed to a depth of at least 1-1/2 inches in the chemical which is delivered to rats in a 9-liter glass exposure chamber. Mean vapor concentration is calculated from the loss in weight of the liquid or estimated from the vapor pressure at the actual temperature of the chemical during aerosol.

Analytical verification of test atmosphere concentrations:

no

Duration of exposure:

8 h

Concentrations:

0.083 mg/l

No. of animals per sex per dose:

6 animals/dose, sex unspecified

Control animals:

not specified

Details on study design:

- Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight

Statistics:

LC50 was calculated by the moving average method based on a 14-day observation period.

Results and discussion

Effect levels

Sex:

not specified

Dose descriptor:

LC50

Effect level:

> 0.083 mg/L air

Exp. duration:

8 h

Mortality:

There were no mortalities.

Clinical signs:

other: No clinical signs were observed.

Body weight:

Weight change: 50-80 g

Gross pathology:

No remarkable findings were observed.