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EC number: 915-673-4 | CAS number: 211519-85-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1991-12-02 to 1991-12-13
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- Guideline study with acceptable restrictions. The study was conducted according to an appropriate OECD test guideline, with acceptable restrictions. The restriction was that the presence of undissolved test material (turbidity) in the water-accommodated fractions may have contributed to effects observed in the test.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- no
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION
- Method: Test media were prepared at nominal loading rates of 1000 and 10000 mg/L by adding appropriate amounts of the test substance to 1.5 litres of the dilution water and stirring for approximately 20 hours at a temperature of 25ºC. The resulting media were allowed to stand for 4 hours before introducing the fish. Fresh test media were prepared for daily renewal.
- Controls: Dilution water
- Evidence of undissolved material (e.g. precipitate, surface film, etc): It is likely that the solubility of the substance in the test medium was exceeded a
t the tested loading rates. Undissolved test substance was observed to be present in the test media. - Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- TEST ORGANISM
- Common name: Zebrafish
- Source: Commercial hatchery; M.B. Ruysbroek B.V., Maassluis, Netherlands
- Length at study initiation (length definition, mean, range and SD): 2.1 +/-0.1 cm
- Weight at study initiation (mean and range, SD): 0.07 +/-0.01 g
- Feeding during test: none - Test type:
- semi-static
- Water media type:
- freshwater
- Total exposure duration:
- 96 h
- Hardness:
- 204 mg/L
- Test temperature:
- 24.3-25.6ºC
- pH:
- 7.7-8.2
- Dissolved oxygen:
- ≥5.6 mg/L
- Nominal and measured concentrations:
- Nominal loading rates: 0(Control), 1000 and 10000 mg/L.
It is likely that the solubility of the substance in the test medium was exceeded at the tested loading rates. Undissolved test substance was observed to be present in the test media. - Details on test conditions:
- TEST SYSTEM
- Test vessel: Beaker
- Type (delete if not applicable): open
- Material, size, headspace, fill volume: glass, 2 litre with 1.5 litres of test medium
- Aeration: yes
- Renewal rate of test solution (frequency/flow rate): daily
- No. of organisms per vessel: 10
- No. of vessels per concentration (replicates): 2
- No. of vessels per control (replicates): 2
- Biomass loading rate: 0.5 g/L
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: DSWL standard water prepared by adding salts to groundwater obtained from near Linschoten, Netherlands
- Total organic carbon: 1.7 mg/L
- Ca/Mg ratio: 1.32 mmol/L Ca2+ : 0.72 mmol/L Mg2+
- Culture medium different from test medium: no data
- Intervals of water quality measurement: daily
OTHER TEST CONDITIONS
- Adjustment of pH: no
- Photoperiod: 16 h light 8 h dark with 30 minute transition
EFFECT PARAMETERS MEASURED (with observation intervals if applicable): mortality after 24, 48, 72 and 96 hours
TEST CONCENTRATIONS
- Spacing factor for test concentrations: 10
- Justification for using less concentrations than requested by guideline: not reported
- Range finding study: yes but results not reported - Reference substance (positive control):
- no
- Duration:
- 96 h
- Dose descriptor:
- LL50
- Effect conc.:
- > 10 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- NOELR
- Effect conc.:
- >= 10 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Details on results:
- - Behavioural abnormalities: none
- Mortality of control: 0
- Other adverse effects control: none
- Effect concentrations exceeding solubility of substance in test medium: The solubility of the substance in the test medium (approximately 0.5 mg/l)was exceeded at the tested loading rates. Undissolved test substance was observed to be present in the test media. - Reported statistics and error estimates:
- There were no effects in any treatment. Statistical analysis of the results was therefore not required.
- Sublethal observations / clinical signs:
There were no toxic effects in either treatment.
- Validity criteria fulfilled:
- yes
- Conclusions:
- A 96-hour LL50 value of >10000 mg/L and NOELR of ≥10000 mg/L have been determined for the effects of the test substance on mortality of Brachydanio rerio. The water solubility of the substance (<1 mg/L) was exceeded at the tested loading rates and undissolved test substance was observed to be present in the test media.
Reference
Description of key information
LL50 (96 h): >10000 mg/l test material (nominal, highest concentration tested), based on the mortality of Danio rerio (OECD Guideline 203 (Fish, Acute Toxicity Test)).
Key value for chemical safety assessment
Additional information
A 96-hour LL50 value >10000 mg/l (nominal) (highest concentration tested) have been determined for the effects of bis[3-(triethoxysilyl)propyl]polysulfides (CAS 211519-85-6, EC 915-673-4) on the mortality of Danio rerio in a test conducted according to OECD TG 203 and in compliance with GLP (Evonik Degussa, 1992b). The water solubility of the substance (<1 mg/l, measured; 0.01 - 0.014 mg/l, estimated) was exceeded at the tested loading rates and undissolved test substance was observed to be present in the test media. It is likely that, because of the prolonged test medium preparation phase, the test organisms were exposed to a mixture of the parent constituents and the hydrolysis products of the constituents, as well as undissolved test substance and/or precipitated oligomeric by-products.
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