Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Workers - Hazard via inhalation route

Systemic effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified
DNEL related information

Local effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified
DNEL related information

Workers - Hazard via dermal route

Systemic effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified
DNEL related information

Local effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified

Workers - Hazard for the eyes

Local effects

Hazard assessment conclusion:
no hazard identified

Additional information - workers

Worker DNELs have not been derived for Pigment Red 170 because the substance did not cause relevant toxictiy in any test performed according to the information requirements.


- the substance did not cause lethal effects in rats after administration of a single oral dose of 15000 mg/kg, a single dermal dose of 2000 mg/kg or a single inhalation exposure to 1580 mg/cubic metre,


- the substance isnot irritating and does not have to be classified as eye or skin irritants,


- the substance caused no relevant systemic toxic effects in a subacute oral study in rats (NOAEL 1000 mg/kg/day),


- a close structural analogue of the substance caused no relevant systemic toxic effects in a subchronic inhalation study in rats (NOAEC 30 mg/m³),


- the substance caused no systemic toxic effects, no effects on fertility or development in a Reproduction / Developmental Toxicity Screening Test (OECD TG 421; NOAEL 1000 mg/kg bw/day),


- a close structural analogue of the substance caused no relevant systemic toxic effects in a two developmental toxicity studies in rats and rabbits (NOAEL 1000 mg/kg/day),


- the absence of effects in the above-mentioned toxicity endpoint tests indicates that the substance does not interact with living cells/tissues, and


- it is unlikely that the substance become systemically bioavailable due to their extremely low solubility in water and low solubility in n-octanol. The substance is not likely to be systemically available after oral, dermal or inhalation exposure.


Therefore no DNELs for systemic effects have been derived.


 


Pigment Red 170 does not cause irritation, corrosion or sensitization. It is considered unlikely to become bioavailable in the skin and is not classified regarding respiratory tract irritation. No substance specific effects are expected for the Pigment Red 170 after local exposure, therefore no DNELs for local effects have been derived. Apart from that, relevant occupational exposure limits for inert dusts should be applied.

General Population - Hazard via inhalation route

Systemic effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified
DNEL related information

Local effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified
DNEL related information

General Population - Hazard via dermal route

Systemic effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified
DNEL related information

Local effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified

General Population - Hazard via oral route

Systemic effects

Long term exposure
Hazard assessment conclusion:
no hazard identified
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified
DNEL related information

General Population - Hazard for the eyes

Local effects

Hazard assessment conclusion:
no hazard identified

Additional information - General Population

DNELs for the general population have not been derived for Pigment Red 170 because the substance did not cause relevant toxictiy in any test performed according to the information requirements.


- the substance did not cause lethal effects in rats after administration of a single oral dose of 15000 mg/kg, a single dermal dose of 2000 mg/kg or a single inhalation exposure to 1580 mg/cubic metre,


- the substance isnot irritating and does not have to be classified as eye or skin irritants,


- the substance caused no relevant systemic toxic effects in a subacute oral study in rats (NOAEL 1000 mg/kg/day),


- a close structural analogue of the substance caused no relevant systemic toxic effects in a subchronic inhalation study in rats (NOAEC 30 mg/m³),


- the substance caused no systemic toxic effects, no effects on fertility or development in a Reproduction / Developmental Toxicity Screening Test (OECD TG 421; NOAEL 1000 mg/kg bw/day),


- a close structural analogue of the substance caused no relevant systemic toxic effects in a two developmental toxicity studies in rats and rabbits (NOAEL 1000 mg/kg/day),


- the absence of effects in the above-mentioned toxicity endpoint tests indicates that the substance does not interact with living cells/tissues, and


- it is unlikely that the substance become systemically bioavailable due to their extremely low solubility in water and low solubility in n-octanol. The substance is not likely to be systemically available after oral, dermal or inhalation exposure.


Therefore, no DNELs for systemic effects have been derived.


 


Pigment Red 170 does not cause irritation, corrosion or sensitization. It is considered unlikely to become bioavailable in the skin and is not classified regarding respiratory tract irritation. No substance specific effects are expected for the Pigment Red 170 after local exposure, therefore no DNELs for local effects have been derived. Apart from that, relevant occupational exposure limits for inert dusts should be applied.