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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Environmental fate & pathways

Bioaccumulation: aquatic / sediment

Currently viewing:

Administrative data

Endpoint:
bioaccumulation in aquatic species: fish
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: TGD guideline, QSAR calculation, acceptable with restrictions
Justification for type of information:
A discussion and report on the read across strategy is given as an attachment in Section 13.
Cross-reference
Reason / purpose for cross-reference:
read-across: supporting information
Reference
Endpoint:
bioaccumulation in aquatic species: fish
Type of information:
read-across based on grouping of substances (category approach)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: TGD guideline, QSAR calculation, acceptable with restrictions
Justification for type of information:
A discussion and report on the read across strategy is given as an attachment in Section 13.
Reason / purpose for cross-reference:
read-across source
Principles of method if other than guideline:
This model uses a parabolic relationship between log Kow and BCF to predict the BCF of a test substance. This parabolic relationship applies to substances with a log Kow >6.
GLP compliance:
no
Remarks:
not applicable
Specific details on test material used for the study:
Details on properties of test surrogate or analogue material (migrated information):
not applicable
Details on sampling:
not applicable
Vehicle:
no
Details on preparation of test solutions, spiked fish food or sediment:
not applicable
Test organisms (species):
Pimephales promelas
Details on test organisms:
not applicable
Route of exposure:
aqueous
Test type:
not specified
Water / sediment media type:
natural water: freshwater
Hardness:
not applicable
Test temperature:
not applicable
pH:
not applicable
Dissolved oxygen:
not applicable
TOC:
not applicable
Salinity:
not applicable
Details on test conditions:
not applicable
Nominal and measured concentrations:
not applicable
Details on estimation of bioconcentration:
not applicable
Type:
other: log BCF
Value:
4.37 dimensionless
Basis:
not specified
Remarks on result:
other: based on a log Kow 8.06
Details on kinetic parameters:
not applicable
Metabolites:
not applicable
Results with reference substance (positive control):
not applicable
Details on results:
not applicable
Reported statistics:
not applicable
Validity criteria fulfilled:
not applicable
Conclusions:
The calculated log BCF is 4.37.
Executive summary:

An experimental BCF is not available for 1 -hexadecene. In the absence of measured data the use of a QSAR to predict the BCF is an appropriate technique to use. The use of the parabolic bioconcentration factor for aquatic organisms QSAR recommended in the Technical Guidance Document (2003) is appropriate for 1 -hexadecene as its log Kow falls within the applicability domain of the model.

Data source

Reference
Reference Type:
publication
Title:
Use of polynomial expressions to describe the bioconcentration of hydrophobic chemicals by fish.
Author:
Connell and Hawker
Year:
1988
Bibliographic source:
Ecotoxicol. Environ. Saf. 16, 242-257.

Materials and methods

Principles of method if other than guideline:
This model uses a parabolic relationship between log Kow and BCF to predict the BCF of a test substance. This parabolic relationship applies to substances with a log Kow >6.
GLP compliance:
no
Remarks:
not applicable

Test material

Constituent 1
Chemical structure
Reference substance name:
Hexadec-1-ene
EC Number:
211-105-8
EC Name:
Hexadec-1-ene
Cas Number:
629-73-2
Molecular formula:
C16H32
IUPAC Name:
hexadec-1-ene
Details on test material:
not applicable
Specific details on test material used for the study:
Details on properties of test surrogate or analogue material (migrated information):
not applicable

Sampling and analysis

Details on sampling:
not applicable

Test solutions

Vehicle:
no
Details on preparation of test solutions, spiked fish food or sediment:
not applicable

Test organisms

Test organisms (species):
Pimephales promelas
Details on test organisms:
not applicable

Study design

Route of exposure:
aqueous
Test type:
not specified
Water / sediment media type:
natural water: freshwater

Test conditions

Hardness:
not applicable
Test temperature:
not applicable
pH:
not applicable
Dissolved oxygen:
not applicable
TOC:
not applicable
Salinity:
not applicable
Details on test conditions:
not applicable
Nominal and measured concentrations:
not applicable
Details on estimation of bioconcentration:
not applicable

Results and discussion

Bioaccumulation factor
Type:
other: log BCF
Value:
4.37 dimensionless
Basis:
not specified
Remarks on result:
other: based on a log Kow 8.06
Details on kinetic parameters:
not applicable
Metabolites:
not applicable
Results with reference substance (positive control):
not applicable
Details on results:
not applicable
Reported statistics:
not applicable

Applicant's summary and conclusion

Validity criteria fulfilled:
not applicable
Conclusions:
The calculated log BCF is 4.37.
Executive summary:

An experimental BCF is not available for 1 -hexadecene. In the absence of measured data the use of a QSAR to predict the BCF is an appropriate technique to use. The use of the parabolic bioconcentration factor for aquatic organisms QSAR recommended in the Technical Guidance Document (2003) is appropriate for 1 -hexadecene as its log Kow falls within the applicability domain of the model.