Registration Dossier
Registration Dossier
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EC number: 238-694-4 | CAS number: 14644-61-2
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- No guideline study with some deficiencies: the rat is a poor animal for the study of experimental hypercholesteremia, requiring special diets and the feeding of cholesterol and saturated fats to develop high serum levels. The data on changes in serum cholesterol with age are incomplete.
Data source
Reference
- Reference Type:
- publication
- Title:
- Serum Cholesterol Levels in Rats Fed Thirteen Trace Elements
- Author:
- Schroeder HA
- Year:
- 1 968
- Bibliographic source:
- J. Nutrition, 94: 475-480
Materials and methods
- Type of study / information:
- Study of the effect of Zr sulfate administration via drinking water on serum cholesterol levels in rats.
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Rats were given soluble salts of zirconium (5 ppm Zr) from the time of weaning until 11 to 30 months of age.
- GLP compliance:
- no
Test material
- Reference substance name:
- zirconium sulfate
- IUPAC Name:
- zirconium sulfate
- Details on test material:
- - Name of test material (as cited in study report): Zirconium sulfate
Constituent 1
Results and discussion
Any other information on results incl. tables
Serum cholesterol levels in mature rats given zirconium (12 rats/sex tested; age of rats: 893 days):
male rats: 89.7 ± 5.6 mg/100 mL
female rats: 100.7 ± 9.0 mg/100 mL
Compared with the controls given 1.0 ppm chromium, values for males were slightly elevated in the group fed zirconium.
Female control levels were the highest of any group. Other elevated values (> 100 mg/100 mL) occurred in the group given zirconium.
The observed effects were not significant.
Changes in circulating cholesterol levels with age: Increases occurred in rats of both sexes fed zirconium.
Applicant's summary and conclusion
- Conclusions:
- Compared with the controls given 1.0 ppm chromium, values for males were slightly elevated in the group fed zirconium.
Female control levels were the highest of any group. Other elevated values (> 100 mg/100 mL) occurred in the group given zirconium.
The observed effects were not significant. Increases in circulating cholesterol levels with age occurred in rats of both sexes fed zirconium.
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