Registration Dossier

Administrative data

Description of key information

Silver nitrate is corrosive or strongly irritating to skin and eyes. Thus, any acute toxicity testing (oral, dermal or inhalation) in animals is not justifiable for silver nitrate based on animal welfare considerations. The acute toxicity of other silver compounds is generally low (LD50, oral all >2000 mg/kgbw for Ag, Ag2O, Ag2CO3, Ag2SO4, AgCl), indicating an overall low systemic toxicity and bioavailability of silver, which is assumed to also pertain to silver nitrate, since the nitrate anion itself is not expected to contribute to a relevant extent to overall toxicity.In consequence, testing for AgNO3 is not considered to be justified and no hazard classification for acute toxicity is required.

Key value for chemical safety assessment

Additional information

Justification for classification or non-classification

Silver nitrate is corrosive or strongly irritating to skin and eyes. Thus, any acute toxicity testing (oral, dermal or inhalation) in animals is not justifiable for silver nitrate based on animal welfare considerations. The acute toxicity of other silver compounds is generally low (LD50, oral all >2000 mg/kgbw for Ag, Ag2O, Ag2CO3, Ag2SO4, AgCl), indicating an overall low systemic toxicity and bioavailability of silver, which is assumed to also pertain to silver nitrate, since the nitrate anion itself is not expected to contribute to a relevant extent to overall toxicity.In consequence, testing for AgNO3 is not considered to be justified and no hazard classification for acute toxicity is required.