Registration Dossier
Registration Dossier
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EC number: 204-646-6 | CAS number: 123-72-8
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data given, comparable to guideline study, limited documentation
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 951
- Report date:
- 1951
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Test type:
- other: Screening based on standard methods
- Limit test:
- no
Test material
- Reference substance name:
- Butyraldehyde
- EC Number:
- 204-646-6
- EC Name:
- Butyraldehyde
- Cas Number:
- 123-72-8
- Molecular formula:
- C4H8O
- IUPAC Name:
- butanal
- Details on test material:
- No information provided
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Carworth-Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- No information provided
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Details on oral exposure:
- No information provided
- Doses:
- no data, probably logarithmic scale (from Smyth et al., Arch. Ind. Hyg Occup. Med 10, 61-68 (1954)
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
- Details on study design:
- No information provided
- Statistics:
- LD50 according to Thompson 1947 (from Smyth et al. J. Ind. Hyg. Toxicol. 31, 60-62 (1949))
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 5 890 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: SD: 5540 mg/kg bw - 6250 mg/kg bw
- Mortality:
- No information provided.
- Clinical signs:
- other: No further information
- Gross pathology:
- No information provided
- Other findings:
- No further information
Any other information on results incl. tables
No additional information
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- GHS: no category (>5000 mg/kg)
- Executive summary:
In an early screening test, an approximate oral LD50 in male and female rats was determined to be 5890 mg/kg bw (SD: 5540 mg/kg bw - 6250 mg/kg bw). The result was obtained within a comprehensive screening testing programme on short-term toxic effects. Results are only documented as toxicity values in tabular form without details on acute adverse effects. Within this scope of restriction and irrespective of the study age, the data is considered reliable.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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