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EC number: 272-817-2
CAS number: 68915-96-8
A complex combination of hydrocarbons produced by the atmospheric distillation of crude oil. It boils in the range of approximately 288°C to 471°C (550°F to 880°F).
a key acute inhalation toxicity study, the test material (CAS no.
64741-44-2) was administered to Sprague-Dawley rats (5/sex/dose) via
inhalation (in air; nose only) at a concentration of 2.53 mg/L for a
period of 4 hours.
animals were observed every 15 minutes for the first hour, and then at
hourly intervals during the exposure period. Detailed
individual observations on all animals were recorded pre-exposure,
immediately post-exposure and then daily for fourteen days. Bodyweights
were recorded for all animals pre-exposure (day 0) and on days 7 and 14
of the study period. Necroscopy was conducted for all surviving animals
at termination and means and standard deviations calculated.
few animals exhibited laboured breathing starting approximately thirty
minutes into the exposure. Incidences of laboured breathing increased as
the exposure progressed, and during the last two hours all animals
exhibited laboured breathing. Individual
animals also displayed decreased activity, a closed eye, clear ocular
discharge, brown ano-genital staining of the fur, and brown material on
the fur of the dorsal lumbar area. Most animals were observed to have
recovered by Day 1 post-exposure (although one male exhibited laboured
breathing). Other abnormalities observed on Day 1 included ungroomed
fur, dry red material around the left eye, brown or yellow ano-genital
staining, and brown material on the fur of the dorsal lumbar area. All
animals appeared normal by Day 3 post-exposure. One animal developed
alopecia on the head from Day 5 through Day 13 and exfoliation on the
dorsal cervical area from Day 5 through Day 9. Another animal had
alopecia of the extremities from Day 7 through 14 post-exposure. Also
observed, were single scattered incidences of scabs on the extremities
and dorsal cervical area. These observations were considered incidental
and probably not related to exposure to the test material. All animals
gained weight throughout the study; weight gains were slightly lower for
the first week than the second week in both sexes.
were no deaths during the study. Necroscopy revealed that 5 animals had
slightly discoloured lungs (mottled in 2 rats and single or small
numbers of dark red foci in 3 rats). This
was probably related to exposure. Other minor abnormalities included
single incidences of enlarged kidneys, discoloured mandibular lymph
nodes and alopecia on the extremities. 4 animals had no macroscopic
upon the results of this study, the four hour acute inhalation LC50 for
the test material was determined to be greater than 2.53 mg/L.
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