Registration Dossier
Registration Dossier
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EC number: 270-726-2 | CAS number: 68477-35-0 A complex combination of hydrocarbons from the distillation of saturated and unsaturated aliphatic hydrocarbons usually ranging in the carbon numbers C3 through C6. It consists of saturated and unsaturated hydrocarbons having carbon numbers in the range of C3 through C6, predominantly piperylenes.
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- Not reported
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP, non-guideline, published in peer reviewed literature, limitations in design and/or reporting but otherwise adequate for assessment
Cross-reference
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- publication
- Title:
- Range-Finding Toxicity Data: List VII
- Author:
- Smyth HF, Carpenter CP, Carrol SW, Urbano CP, Streigel JA, Nycum JS
- Year:
- 1 969
- Bibliographic source:
- Am. Ind. Hyg. Assoc. J. Vol 30, 470-476
Materials and methods
- Principles of method if other than guideline:
- Single dermal application followed by 14 days observation.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Cyclopentene
- EC Number:
- 205-532-9
- EC Name:
- Cyclopentene
- Cas Number:
- 142-29-0
- Molecular formula:
- C5H8
- IUPAC Name:
- cyclopentene
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
Weight at study initiation: 2.5-3.5 kg
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- not specified
- Details on dermal exposure:
- Technique used based on the one-day cuff method of Draize and associates. Fur removed from entire trunk by clipping and dose retained beneath an impervious plastic film. Animals immobilised during the 24 hour application period after which film is removed.
- Duration of exposure:
- 24 hours
- No. of animals per sex per dose:
- 4
- Control animals:
- not specified
- Details on study design:
- Duration of observation period following administration: 14 days
- Statistics:
- Dermal LD50 (and its fiducial range) estimated by the method of Thompson (Thompson WR, 1947) using the Tables of Weil (Weil CS, 1952)
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 1 183 mg/kg bw
- Remarks on result:
- other: (1.59 ml/kg bw)
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 1.59 mL/kg bw
- 95% CL:
- 0.97 - 2.59
Applicant's summary and conclusion
- Conclusions:
- The acute dermal LD50 of cyclopentene to male rabbits was 1.59 mL/kg (0.97-2.59). Assuming a density of 0.744g/ml, Rabbit Dermal LD50 = 1183mg/kg.
- Executive summary:
In a range-finding acute dermal toxicity study,using the same experimental methods as described in an earlier publication (Smyth et al, 1962), the acute dermal LD50 of cyclopentene to male rabbits was 1.59 mL/kg (0.97-2.59). Assuming a density of 0.744g/ml, Rabbit Dermal LD50 = 1183mg/kg
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