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EC number: 218-690-9 | CAS number: 2216-51-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Study period:
- No study period is specified in the report, but the study report was finalized on 1974-06-27.
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: According to ECVAM ToxRTool reliability 2. Only a short description of the study is given in the present report and few experimental details are provided. Study was conducted before the implementation of GLP.
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 974
- Report date:
- 1974
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The acute oral toxicity of racemic menthol was determined in female Wistar rats (n=10 per dose). The test item (10-20 mL/kg) was applied by gavage at dose levels of 2; 2,5, 3; and 3,5 g/kg bw in peanut oil. The animals were observed for 14 d post-dose. LD50 values were calculated from the experimental data using Probit analysis.
- GLP compliance:
- no
- Remarks:
- The study was conducted before the implementation of GLP.
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Menthol racemisch
- IUPAC Name:
- Menthol racemisch
- Reference substance name:
- Menthol
- EC Number:
- 201-939-0
- EC Name:
- Menthol
- Cas Number:
- 89-78-1
- IUPAC Name:
- 2-isopropyl-5-methylcyclohexanol
- Details on test material:
- No details were provided.
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- peanut oil
- Details on oral exposure:
- The animals received a single oral dose of the test item via gavage. The test item was administered in peanut oil.
- Doses:
- The test item was administered at dose levels of 2; 2,5, 3; and 3,5 g/kg bw.
- No. of animals per sex per dose:
- 10 females were used per dose.
- Control animals:
- no
- Details on study design:
- Female Wistar rats (n=10 per dose) received a single oral dose dose of the test item in peanut oil item via gavage. The test item was administered at dose levels of 2; 2,5, 3; and 3,5 g/kg bw. The animals were observed for 14 d post-dose. LD50 values were calculated from the experimental data using Probit analysis.
- Statistics:
- LD50 values were calculated from the experimental data using Probit analysis.
Results and discussion
- Preliminary study:
- no preliminary study
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 2 602 mg/kg bw
- 95% CL:
- > 2 328 - < 2 861
- Mortality:
- Please, see section "Any other information on results incl. tables" for the mortality rates observed at the different dose levels. In the animals that died, death occurred within 1 to 3 d after administration of the test item.
- Clinical signs:
- other: 1-3 days after application animals were in a narcosis-like state.
- Gross pathology:
- no data
- Other findings:
- no data
Any other information on results incl. tables
Table 1: Acute toxicity of "Menthol racemisch 100" in female rats
Dose (g/kg) |
No. of animals used |
No. of animals that died |
2 |
10 |
1 |
2,5 |
10 |
4 |
3 |
10 |
7 |
3,5 |
10 |
10 |
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- In this acute oral toxicty study in female Wistar rats, the LD50 of racemic menthol was determined as 2,602 g/kg bw (range: 2,328-2,861 g/kg bw). Accordingly, the acute toxicity of the test item can be considered low.
- Executive summary:
In an acute oral toxicity study in female Wistar rats (n=10 per dose), racemic menthol was administered by gavage at dose levels of 2; 2,5, 3; and 3,5 g/kg bw in peanut oil. The animals were observed for 14 d post-dose. LD50 values were calculated from the experimental data using Probit analysis.
The LD50 of racemic menthol was determined as 2,602 g/kg bw (range: 2,328 -2,861 g). Accordingly, the acute toxicity of the test item can be considered low.
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