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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:
There is a complete absence of any human studies of adequate quality that can be used for assessing the sensitising potential of diantimony trioxide. However, there is one reliable animal study (Chevalier, 2005), performed according to TG 406 and GLP, which shows that diantimony trioxide has no sensitising properties.

Migrated from Short description of key information:

Diantimony trioxide is not a skin sensitiser.

Justification for selection of skin sensitisation endpoint:

Key study

Respiratory sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:
Based on an industry survey, during many years of industrial practice no cases of hypersensitivity were observed till now by workers exposed exclusively to diantimony trioxide.

Migrated from Short description of key information:

Diantimony trioxide is not a respiratory sensitiser.

Justification for classification or non-classification

Sensitisation:

 

The reference Chevalier F. (2005), is considered as the key study on skin sensitisation and will be used for classification. The overall sensitisation results are as follows:

 

Moore, G.E.(1994) – Buehler method in guinea pigs

The incidence of sensitisation after the challenge application was 0/20. Thus, the classification criteria according to regulation (EC) 1272/2008 as skin sensitizer are not met since 0 % of the test animals responded.

 

Respiratory sensitisation:

Based on an industry survey, during many years of industrial practice no cases of hypersensitivity were observed till now by workers exposed exclusively to diantimony trioxide. Thus, no classification as respiratory sensitiser according to regulation (EC) 1272/2008 is required.