Manganese

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

19 December 2008 to 11 February 2009

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: GLP and to a current guideline.

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

Deviations:

yes

Remarks:

flask method used instead of column elution method

Principles of method if other than guideline:

Deviation: The preliminary water solubility test indicated that the column elution method should have been performed as the solubility was less than 1 x 10-2 g/l. However, in the absence of a suitable volatile organic solvent for the coating of inorganic substances onto a suitable support material, this method could not be used. Experience has shown that when the support material is coated by substances present as a suspension in a solvent, as opposed to a true solution, the test material breaks away from the support material over time, migrating into the reservoirs and invalidating the determination, therefore the column elution method was used.

GLP compliance:

yes (incl. QA statement)

Type of method:

flask method

Water solubility:

0.001 g/L

Temp.:

20 °C

pH:

> 5.3 - < 5.5

Details on results:

Water solubility: 0.7 mg/L of manganese in solution at 20.0 ± 0.5 ºC.

Preliminary estimate of water solubility was less than 7.0 x 10^-4

Definitive test results:

Sample number	Time shaken at ca. 30 °C (hours)	Time equilibrated at 20 °C (hours)	Manganese concentration (g/l)	Equivalent test material concentration (g/l)	Solution pH
1	24	24	7.5 x 10^-4	7.5 x 10^-4	5.5
2	48	24	8.2 x 10^-4	8.2 x 10^-4	5.3
3	72	24	5.3 x 10^-4	5.3 x 10^-4	5.5

This was equivalent to 7.0 x 10^-4 g/L of test material in solution at 20.0 ± 0.5 °C based on the manganese content of the test material.

Conclusions:

Interpretation of results: Slightly soluble (0.1-100 mg/L)
The water solubility of the test material has been determined to be 0.7 mg/L of manganese in solution at 20.0 ± 0.5 ºC. This was equivalent to 0.7 mg/L of test material in solution at 20.0 ± 0.5 ºC based on the manganese content of the test material.

Description of key information

Interpretation of results: Slightly soluble (0.1-100 mg/L)
The water solubility of the test material has been determined to be 0.7 mg/L of manganese in solution at 20.0 ± 0.5 ºC. This was equivalent to 0.7 mg/L of test material in solution at 20.0 ± 0.5 ºC based on the manganese content of the test material.

Key value for chemical safety assessment

Water solubility:

0.7 mg/L

at the temperature of:

20 °C