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EC number: 232-366-4
CAS number: 8008-20-6
A complex combination of hydrocarbons produced by the distillation of crude oil. It consists of hydrocarbons having carbon numbers predominantly in the range of C9 through C16 and boiling in the range of approximately 150°C to 290°C (320°F to 554°F).
for irritation was extended to 10 days. Although the degree of edema
declined throughout the observation period, the
degree of erythema and eschar did not decline so markedly. Scores for
the range of erythema and edema as well as the average irritation
scores and their ranges are summarised in the following table.
Range of scores
On the basis of these findings, the test material was described as
a primary dermal irritation study, 6 female New Zealand White rabbits
were dermally exposed to undiluted Kerosine/heating oil (0.5mL per test
of the test
sites on each rabbit were
intact skin. After exposure, the test site was
covered with a gauze pad and the trunk of the rabbit was wrapped
in an impervious covering. Twenty-four
hours later the patches were
removed and any residual material was wiped from the skin. Each of the
test sites was evaluated for skin responses within 60 minutes of
patch removal (24 hour reading), and again at 72 hours, then daily until
9 days post-application. The responses were scored using the Draize scale.
mean erythema and edema scores over 72 hours (i.e., average of 24 and 72
hour readings) were 3.46 and 2.33 for intact skin for each endpoint
respectively. The test material was classified as irritating according
to EU criteria.
This study received a Klimisch score of 2
and is classified as reliable with restrictions because it is an
acceptable and well-documented study report.
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