Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 202-826-9 | CAS number: 100-18-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Adsorption / desorption
Administrative data
Link to relevant study record(s)
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2011
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- The study was conducted using a documented method and in compliance with GLP.
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.19 (Estimation of the Adsorption Coefficient (KOC) on Soil and Sewage Sludge Using High Performance Liquid Chromatography (HPLC))
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- HPLC estimation method
- Media:
- soil/sewage sludge
- Specific details on test material used for the study:
- Sponsor's identification p-diisopropylbenzene
Description Clear, colourless liquid
CAS number 100-18-5
Purity Not supplied
Date received 31 August 2011
Expiry date Not supplied
Storage conditions Room temperature, in the dark - Radiolabelling:
- no
- Details on study design: HPLC method:
- EQUIPMENT
HPLC system: Agilent technologies 1100 incorporating auto sampler
Column: Luna 5 μm CN (150* 4.6 mm id)
Column temperature: 30 °C
Mobile phase: methanol : water (55 : 45 v/v)
pH of mobile phase: 6.2
Flow-rate: 1.0 mL/min
Injection volume: 10 μL
UV detector wavelengh: 210 nm
DETERMINATION OF DEAD TIME
- Method: The dead time was determined by measuring the retention time of formamide (purity* 99.94 %) at 664 mg/L in mobile phase.
REFERENCE SUBSTANCES
- Identity: Acetanilide, phenol, atrazine, isoproturon, triadimenol, linuron, naphthalene, endosulfan-diol, fenthion, α-Endosulfan, phenanthrene, DDT - Type:
- log Koc
- Value:
- 3.8
- Temp.:
- 30 °C
- Remarks on result:
- other: Recorded temperature was column temperature.
- Details on results (HPLC method):
- - Retention times of reference substances used for calibration:
Formamide: 1.985 min. (Dead-time)
acetanilide: 2.343 min.
phenol: 2.405 min.
atrazine: 2.743 min.
isoproturon: 2.971 min.
triadimenol: 3.141 min.
linuron: 3.503 min.
naphthalene: 4.451 min.
endosulfan-diol: 3.489 min.
phenanthrene: 5.258 min.
α-endosulfan: 6.006 min.
phenanathrene: 7.315 min.
DDT: 14.818 min.
- Details of fitted regression line (log k' vs. log Koc):
y = 0.3374 x- 1.0141 R^2 = 0.9554
- Average retention data for test substance: 5.658 min. - Validity criteria fulfilled:
- yes
- Conclusions:
- The adsorption coefficient (Koc) of the test item has been determined to be 6.28 x 10E3, log10 Koc 3.80.
- Executive summary:
6.28 x 103, log10Koc 3.80, using the HPLC screening method, designed to be compatible with Method C19 Adsorption Coefficient of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 121 of the OECD Guidelines for Testing of Chemicals, 22 January 2001.
Reference
The retention times, capacity factors and logio Koc values determined for the sample are shown in the following table:
Peak | Retention time (mins) | Capacity factor (k) | Log10 k | Log10 Koc | ||
injection 1 | injection 2 | Mean | ||||
1 | 5.661 | 5.656 | 5.658 | 1.85 | 0.267 | 3.80 |
Log10 Koc : 3.80
Adsorption coefficient: 6.28* 103
Discussion
The mobile phase was used at an approximately neutral pH as the test item had no dissociation constants within the environmentally relevant pH range.
Description of key information
6.28 x 103, log10Koc 3.80, using the HPLC screening method, designed to be compatible with Method C19 Adsorption Coefficient of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 121 of the OECD Guidelines for Testing of Chemicals, 22 January 2001.
Key value for chemical safety assessment
- Koc at 20 °C:
- 6 280
Additional information
The adsorption coefficient (Koc) of the test item has been determined in a study according to EU Method C.19 (Estimation of the Adsorption Coefficient (KOC) on Soil and Sewage Sludge Using High Performance Liquid Chromatography (HPLC)). The mobile phase was used at an approximately neutral pH as the test item had no dissociation constants within the environmentally relevant pH range.
The adsorption coefficient (Koc) of the test item has been determined to be 6.28 x 10E3, log10 Koc 3.80.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.