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EC number: 201-142-8 | CAS number: 78-78-4
The results of the Ames test with the highest non-toxic dose are presented below. The positive control was mutagenic in strains TA98 and TA100, and was slightly mutagenic in strain TA1535. n-Pentane was toxic at concentrations of 25 and 50%, so additional tests were conducted to determine whether the compound was mutagenic at lower concentrations (1, 2, 5, 8 and 10%). Results show that n-pentane is not mutagenic at the lower concentrations.
Concentration of Gas in the Desiccator (V/V) %
Average histidine revertants per plate
Positive control (methylene chloride)
The genetic toxicity in bacteria of n-pentane was evaluated via an Ames test. The statistical methods used were appropriate. The test conditions complied with the guideline requirements for this study type.
n-Pentane was not found to be mutagenic at any concentration in both the presence and absence of S9 mix
This study is classified as reliable with restrictions, Klimisch score 2, because no information regarding GLPs was provided. However, the study closely followed OECD 471 and EEC B.13/14. The standard plate test was modified due to the gaseous nature of the chemicals; these modifications did not affect the overall study results. One of the strains used (TA1538) is not included in the current Guidelines, and only data from the highest dose was presented in the study report.
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