Phthalic anhydride

Additional toxicological data

Administrative data

Endpoint:

additional toxicological information

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: well documented and scientifically acceptable

Data source

Reference

Reference Type:

publication

Title:

Heterogeneity of specific-IgE responses in workers sensitized to acid anhydride compounds

Author:

Bernstein DI, Gallagher JS, D'Souza L, Bernstein IL

Year:

1984

Bibliographic source:

J. Allergy Clin. Immunol. 74, 794 - 801.

Materials and methods

Type of study / information:

Type: other

Principles of method if other than guideline:

Acid anhydride compounds cause IgE-mediated respiratory sensitization in the workplace. In this study reaginic responses in 4 workers sensitized to phthalic anhydride (PA), hexahydrophthalic (HHPA), or himic anhydride (HA) were determined by direct RAST by use of PA-human serum albumin (HSA), HPPA-HSA, and HA-HSA methylcellulose disc substates. RAST inhibition of binding to anhydride-HSA substrates was done with various concentrations of sodium salts, lysine, and HSA conjugates of PA, HHPA, HA, and trimellitic anhydride (TMA) in order to characterize cross-reactivity and spicificity of humoral responses in these workers.

Test material

Test material information

Constituent 1

Reference substance name:

Phthalic anhydride

EC Number:

201-607-5

EC Name:

Phthalic anhydride

Cas Number:

85-44-9

Molecular formula:

C8H4O3

IUPAC Name:

1,3-dihydro-2-benzofuran-1,3-dione

Results and discussion

Any other information on results incl. tables

Cross reactivity of IgE induced by different anhydrides was reported.

Applicant's summary and conclusion

Executive summary:

Acid anhydride compounds cause IgE-mediated respiratory sensitization in the workplace. In this study reaginic responses in 4 workers sensitized to phthalic anhydride (PA), hexahydrophthalic (HHPA), or himic anhydride (HA) were determined by direct RAST by use of PA-human serum albumin (HSA), HPPA-HSA, and HA-HSA methylcellulose disc substates. RAST inhibition of binding to anhydride-HSA substrates was done with various concentrations of sodium salts, lysine, and HSA conjugates of PA, HHPA, HA, and trimellitic anhydride (TMA) in order to characterize cross-reactivity and spicificity of humoral responses in these workers. cross reactivity of IgE induced by different anhydrides was reported. there was a good correlation between hig levels of RAST binding and symptoms of occupational asthma.