Registration Dossier
Registration Dossier
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EC number: 701-006-2 | CAS number: 30008-10-7
Endpoint summary
Administrative data
Description of key information
Additional information
The aquatic toxicity of the target substance sodium 4-hydroxyphenolate (EC 701-006-2) was determined by read-across from the harmonized classification for hydroquinone (EC 204-617-8). The target molecule, Sodium 4-hydroxyphenolate has the same molecular structure as the free phenol hydroquinone, with the exception that one proton on one of the phenolic group is replaced by sodium. In aqueous solution, both substances have a pH-dependent equilibrium, which is governed by the pKa value of the phenolic hydrogens (ca. 9.95 in water). Similarly physiological systems, the protonated/deprotonated equilibrium between the salt form sodium 4-hydroxyphenolate and the free phenol form hydroquinone is pH dependent in environmental aqueous systems. The source and target chemical have a similar water solubility and pKa. It is then expected that they will have a similar behavior in ecosystems. As a conclusion, the aquatic toxicity of sodium 4-hydroxyphenolate is estimated to be similar to that of hydroquinone.
Sodium 4-hydroxyphenolate (EC 701-006-2) is classified as hazardous to the aquatic environment Category Acute 1 and Category Chronic 1, based on a read-across from the harmonized classification for hydroquinone (EC 204-617-8).
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