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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation / corrosion
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
unsuitable test system

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1940
Report date:
1940

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Skin irritation was tested using undiluted test substance or 50% aquaeous solution on the skin of animals ears under occlusive condition for 24 h.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
ε-caprolactam
EC Number:
203-313-2
EC Name:
ε-caprolactam
Cas Number:
105-60-2
Molecular formula:
C6H11NO
IUPAC Name:
azepan-2-one
Specific details on test material used for the study:
- Name of test material (as cited in study report): Luran N (E-Caprolactam)

Test animals

Species:
rabbit
Strain:
not specified

Test system

Type of coverage:
occlusive
Preparation of test site:
not specified
Vehicle:
not specified
Controls:
not specified
Duration of treatment / exposure:
24 hour(s)
Observation period:
no data
Number of animals:
2 for undiluted test substance
2 for 50% aqueous solution

Results and discussion

Any other information on results incl. tables

Application of concentrated undiluted test substance: mild redness, ear swelling and increasing size of vessels.
Application of 50% aqueous solution: no findings

Applicant's summary and conclusion

Interpretation of results:
study cannot be used for classification
Conclusions:
Mild redness, ear swelling and increasing size of vessels were observed after application of concentrated undiluted test substance. Application of 50% aqueous solution showed no findings.
Executive summary:

Skin irritation was tested in rabbits using undiluted test substance or 50% aquaeous solution on the skin of animals ears under occlusive condition for 24 h. 2 rabbits were tested per condition. Results show mild redness, ear swelling and increasing size of vessels after application of concentrated undiluted test substance. Application of 50% aqueous solution showed no findings.