Registration Dossier
Registration Dossier
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EC number: 205-769-8 | CAS number: 150-76-5
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Documentation insufficient for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Short-term toxicity tests on the mono and di methyl ethers of hydroquinone
- Author:
- Hodge HC, Sterner JH, Maynard EA and Thomas J .
- Year:
- 1 949
- Bibliographic source:
- The Journal of Industrial Hygiene and Toxicolology, 31(2), 79-92.
Materials and methods
- Principles of method if other than guideline:
- Other (see Test conditions)
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Mequinol
- EC Number:
- 205-769-8
- EC Name:
- Mequinol
- Cas Number:
- 150-76-5
- Molecular formula:
- C7H8O2
- IUPAC Name:
- 4-methoxyphenol
- Details on test material:
- Monomethyl ether hydroquinone (PMP). No other information available.
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- not specified
- Doses:
- 4, 8, 10, 11, 12, 14, 16, 18 mg/mouse
- No. of animals per sex per dose:
- 10 to 22 per dose
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- ca. 430 mg/kg bw
Any other information on results incl. tables
Dose No. Mean body Mortality Equiv. dose
(mg) mice weight(g) (%) (mg/kg bw)
--------------------------------------------------------------------
4 22 26 0 154
8 22 27 5 296
10 20 25 50 400
11 20 29 65 379
12 20 27 40 444
14 20 28 85 500
16 22 27 82 593
18 10 28 100 643
- Clinical signs: mice developed a wobbly gait immediately following injection. This was followed in a few minutes by paralysis of the hind
quarters, accompanied by spasms perhaps of anoxial origin. At the higher dose the mice appeared to be in a narcosis about 15 minutes
after injection. Some mice still exhibited degrees of anesthesia as long as 18 hours after the injection.
- Body weight and weight gain: data not available.
- Gross pathology: data not available.
The LD50 is of the order of 430 mg/kg bw.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
