Registration Dossier
Registration Dossier
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EC number: 224-832-0 | CAS number: 4511-42-6
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- genetic toxicity in vitro
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Review publication
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Safety assessment of glycolic acid, ammonium, calcium, potassium, and sodium glycolate, methyl, ethyl, ptopyl, and butyl glycolate, and lactic acid, ammonium calcium, potassium, sodium, and TEA-lactate, methyl, ethyl, isopropyl, and butyl lactate, and
- Author:
- Andersen, F.A.
- Year:
- 1 997
- Bibliographic source:
- Cosmetic Ingredients Review, final report. International Journal of Toxicology, Vol.17, Suppl.1.
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- other
- GLP compliance:
- no
- Type of assay:
- other: Review on several mutagenicity studies with lactic acid and some lactates
Test material
- Reference substance name:
- L-(+)-lactic acid
- EC Number:
- 201-196-2
- EC Name:
- L-(+)-lactic acid
- Cas Number:
- 79-33-4
- IUPAC Name:
- 2-hydroxypropanoic acid
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- other: various
- Metabolic activation:
- with and without
- Test concentrations with justification for top dose:
- Various
Results and discussion
Test results
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Remarks on result:
- other: other: Various
- Remarks:
- Migrated from field 'Test system'.
Any other information on results incl. tables
The results of 11 studies are reviewed.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative
Lactic acid is considered not genotoxic.
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