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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

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Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Justification for type of information:
For details and justification of read-across please refer to the read-across report attached to IUCLID section 13.
Reason / purpose for cross-reference:
read-across source
Transformation products:
not measured
21 °C
Hydrolysis rate constant:
ca. 0.23 h-1
ca. 3 h
(pseudo-)first order (= half-life)
Validity criteria fulfilled:
At 21 °C a hydrolysis half-life of 3 h (k = 0.23 h^-1) was determined for L-lactide. The expermiments are, however, very poorly documented, not allowing an assessment of reliability. The study is considered to be invalid.
Executive summary:

Hydrolyis experiments with L-lactide are reported in a published paper, but methods and results are very poorly documented. Analytical methods, employed pH, buffers (if relevant), sterility of equipment, initial and measured concentrations, or any other crucial conditions, were not reported. The study is thus considered to be unreliable.

The half-life of L-lactide in water at 21 °C was determined to be 3 h, corresponding to a rate constant of 0.23 h–1.

This information is used in a read-across approach in the assessment of the target substance. For details and justification of read-across please refer to the read-across report attached to IUCLID section 13.
Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:
the study does not need to be conducted because the substance is readily biodegradable

Description of key information

According to Annex VIII, point, column 2 of the REACH Regulation, a hydrolysis study does not need to be conducted if the substance is readily biodegradable or highly insoluble in water. D-lactide is predicted to be readily biodegradable hence a hydrolysis study is not considered to be required.

Key value for chemical safety assessment

Additional information