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EC number: 215-237-7 | CAS number: 1314-60-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
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- Endpoint summary
- Stability
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- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
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- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
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- Specific investigations
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- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2004-12-10 - 2005-04-06
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 005
- Report date:
- 2005
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Version / remarks:
- , adopted 2001-12-17
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- Diantimony pentoxide
- EC Number:
- 215-237-7
- EC Name:
- Diantimony pentoxide
- Cas Number:
- 1314-60-9
- Molecular formula:
- O5Sb2
- IUPAC Name:
- bis(λ⁵-antimony(5+)) pentaoxidandiide
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Harlan UK Ltd, Bicester
- Age at study initiation: 8 to 10 weeks
- Weight at study initiation: 143 - 171 g
- Fasting period before study: A period of overnight fasting prior to dosing which continued until approximately three hours after dosing.
- Housing: The animals were housed in groups of up to five during the acclimatisation period in cages that conform to the 'Code of Practice for the Housing and Care of Animals Used in Scientific Porcedures' (Home Office, London, 1989). From the day prior to dosing, the rats were housed in groups of three in similar cages.
- Diet (ad libitum): SQC(E) Rat and Mouse maintenance Diet No 1, from Special Diets Services Ltd, Witham
- Water (ad libitum): Main water
- Acclimation period: 8 to 14 days
All animals were given a clinical inspection for ill health on arrival and a sample was weighed.
ENVIRONMENTAL CONDITIONS
- Temperature: 19 to 25 °C
- Relative humidity: 40 to 70 %
- Air changes: At least 15 air changes per hour
- Photoperiod (hrs dark / hrs light): 12/12
No further information on the test animals was stated.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: 1 % w/v aqueous methyl cellulose
- Details on oral exposure:
- VEHICLE
- Justification for choice of vehicle: The vehicle was chosen because it gave the most satisfactory results in pre-study formulation trials.
MAXIMUM DOSE VOLUME APPLIED: Individual doses (mL) were calcualted using the fasted body weights of the rats on the morning of dosing and the dose volume of 10 mL/kg.
DOSAGE PREPARATION: The test article was dispersed in 1 % w/v aqueous methyl cellulose. The formulated concentrations were calculated from the selected dose level and the dose volume of 10 mL/kg. All formulations were used within two hours of preparation.
The formaultions were maintained on a magnetic stirrer prior to administration to ensure homogeneity.
CLASS METHOD
- Rationale for the selection of the starting dose: Since there were no data to indicate that deaths may occur at dose levels of less than 2000 mg/kg, the first dose level was 2000 mg/kg.
No further information on oral exposure was stated. - Doses:
- 2000 mg/kg
- No. of animals per sex per dose:
- 2 groups of 3 females each
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Clinical signs were recorded at approximately 15 and 30 minutes post-dose, hourly between 1 and 4 hours post-dose (inclusive), twice daily on Days 2, 3 and 4 and once daily from the fifth to last day of the observation period. Rats were weighed one day before dosing and on Days 1 (dosing), 4, 8 and 15.
- Necropsy of survivors performed: Yes; Rats were killed by intraperitoneal injection of sodium pentobarbitone on Day 15. After exsanguination a full macroscopic necropsy was performed and all lesions recorded. The necropsy procedure included inspection of external surfaces and orifices, all viscera and tissue within the abdominal, thoracic and cranial cavities, free-hand sectioning of the liver and kidneys and examination of representative sections of mucosal surfaces of the stomach, small and large intestines.
No further information onstudy design was stated.
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- There were no deaths following a single oral dose of EFR-6N (Diantimony pentoxide) among rats dosed at 2000 mg/kg.
- Clinical signs:
- other: No clinical signs were seen.
- Gross pathology:
- No marcoscopic changes were observed for animals killed on Day 15.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute median lethal oral dose was found to exceed 2000 mg/kg.
According to the criteria specified by Directive 67/548/EEC and subsequent regulations, the test item is not classified.
According to the EC Regulation No. 1272/2008 and subsequent regulations, the test item is not classified.
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