Registration Dossier
Registration Dossier
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EC number: 940-005-3 | CAS number: -
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
There are no experimental studies on the toxicokinetics of the test substance, Reaction product of Saccharose, Glycerine, biodiesel propoxylated. The available physico-chemical data(vapor pressure 0.000295 Pa at 25°C, and logP >6.2, respectively) indicate that inhalation of the vapor will be limited. In addition, the logP value of >6 suggests limited absorption across the skin, as stated in ECHA’s Guidance on information requirements and chemical safety assessment, Chapter R.7c: Endpoint specific guidance, Table R.7.12-3).
Illing and Barratt (2007) have extensively discussed a number of NLP polyols with regard to grouping and toxicokinetics assessment. In accordance with this report, sucrose, glycerol, oleic/linoleic acid (the core substances) and propane-1,2-diol and oligomers (the propoxylated side chains) can be considered possible models for the toxicokinetic behavior and the toxicity of the test substance. The approach employed was to examine data for the repeating unit (propane-1,2-diol) and the initiating agents (sucrose, glycerol), and of resulting NLP polyols. Some additional information available from oligomers of propane-1,2-diol and the fatty esters of sucrose were also included. Conclusions for the longer oligomers are based on those data and on structure activity information. With regard to core molecules, Illing and Barratt’s report covers sucrose and glycerol. Oleic acid and linoleic acid, being the main constituents of the biodiesel contained in the test substance, were therefore evaluated separately.
In conclusion, all of the core molecules contained in the test substance, Reaction product of Saccharose, Glycerine, biodiesel propoxylated, can be considered to be essentially non-toxic. Following the argumentation by Illing and Barratt, it can be anticipated that propoxylation of a non-toxic core molecule results in a non-toxic polyol, and that potential degradation products of this polyol will also be non-toxic.
Partly cited from: Illing, H.P.A., and Barratt, M.D. (2007). Grouping of NLP ‘Polyols’ and their toxicokinetics assessments. Prepared for European Diisocyanate and Polyols Producers Association. (ISOPA, unpublished report) (Report attached to chapter 13 of the IUCLID)
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