Methyl benzoylformate

Hydrolysis

Link to relevant study record(s)

Reference

Endpoint:

hydrolysis

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2015

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 111 (Hydrolysis as a Function of pH)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Radiolabelling:

no

Analytical monitoring:

yes

Buffers:

- pH: 4, 7 and 9
- buffer pH 4.00 (Bernd Kraft; citric acid, sodium chloride, sodium hydroxide); buffer pH 7.00 (Bernd Kraft; phosphate mixture); buffer pH 9.00 (Bernd Kraft; boric acid, potassium chloride, sodium hydroxide); buffer pH = 4.008 (Fluka), buffer pH = 9.180 (Fluka) for testing of pH meter

Details on test conditions:

TEST SYSTEM
- Method according OECD 111

Positive controls:

not specified

Negative controls:

not specified

Transformation products:

no

Details on hydrolysis and appearance of transformation product(s):

No hydrolysis products could be observed in any test (pH 4, pH 7 and pH 9) under the analytical conditions applied. lt was observed that the peak shape differed with the applied buffer.

pH:

4

Temp.:

20 °C

Hydrolysis rate constant:

0.003 h-1

DT50:

248.5 h

Type:

(pseudo-)first order (= half-life)

pH:

4

Temp.:

25 °C

Hydrolysis rate constant:

248.5 h-1

DT50:

150 h

Type:

(pseudo-)first order (= half-life)

pH:

7

Temp.:

20 °C

Hydrolysis rate constant:

0.219 h-1

DT50:

3.2 h

Type:

(pseudo-)first order (= half-life)

pH:

7

Temp.:

25 °C

Hydrolysis rate constant:

0.44 h-1

DT50:

1.6 h

Type:

(pseudo-)first order (= half-life)

pH:

9

Temp.:

20 °C

Hydrolysis rate constant:

20.905 h-1

DT50:

0.03 h

Type:

(pseudo-)first order (= half-life)

pH:

9

Temp.:

25 °C

Hydrolysis rate constant:

37.452 h-1

DT50:

0.02 h

Type:

(pseudo-)first order (= half-life)

Details on results:

The degradation reaction measured by pH 4, pH 7 and pH 9 can be assumed to be first or pseudo-first order. Due to this the half-lives for 20°c and 25°C can be calculated.

The degradation reaction measured by pH 4, pH 7 and pH 9 can be assumed to be first or pseudo-first order. Due to this the half-lives for 20°c and 25°C can be calculated.

Validity criteria fulfilled:

yes

Conclusions:

In an acidic environment (pH 4) the substance will hydrolyse slowly. However, in a neutral and in an alkaline environment (pH 7 and 9) the substance will hydrolyse rapidly.

Executive summary:

In this OECD 111 guideline study, the test material (EC 239-263-3) was determined to hydrolyse slowly at pH 4 (half life 150-248.5 hours), and rapidly at pH 7 (half life 1.6-3.2 hours) and pH 9 (half life 0.02-0.03 hours). Tests conducted in duplicate at 20 ºC and 25 ºC respectively.

Description of key information

 Study carried out according to guideline and with GLP compliance. 

Key value for chemical safety assessment

Half-life for hydrolysis:

3.2 h

at the temperature of:

20 °C

Additional information

A GLP guideline study according OECD 111 has been conducted (BASF SE 2015). Following Half-lives have been calculated:

pH value	Temperature [°C]	t1/2[h]
pH 4	20 °C	248.5
pH 4	25 °C	150.0
pH 7	20 °C	3.2
pH 7	25 °C	1.6
pH 9	20°C	0.03
pH 9	25°C	0.02

Therefore, in an acidic environment (pH 4) the substance will hydrolyse slowly. However, in a neutral and in an alkaline environment (pH 7 and 9) the substance will hydrolyse rapidly.