Registration Dossier
Registration Dossier
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EC number: 211-637-0 | CAS number: 677-21-4
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Additional information
Justification for classification or non-classification
The 1-hour LC50 in mice was 1750 mg/m3 (446000 ppm) when tested as a vapour (Dow, 1965). The conversion to a 4-hour LC50 for a gas yielded a value of 223000 ppm. In a second mouse study, the 2-hour LC50 was reported as 1691 mg/m3 (431000 ppm), which was converted to a 4-hour LC50 of 304763 ppm for a gas (Bandman et al., 1990). A 7-hour LC50 in rats of >10000 ppm was also reported (Lu et al., 1953). Therefore the test substance does not need to be classified for acute inhalation according to EU Directive 67/548/EEC and the EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.
However, in the acute inhalation study in mice, clinical observations were observed that included inactivity, dyspnea, salivation, anaesthesia, loss of righting reflex, excitation, and ataxia. Gross necropsy revealed no significant effects attributable to the test article. Based on the anaesthesia, loss of righting reflex, and ataxia, the test substance is classified as R67 (Vapours may cause drowsiness and dizziness) according to EU Directive 67/548/EEC andSTOT Single Exp. 3 (H336: May cause drowsiness or dizziness) according to EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.
References:
Bandman AL et al. (1990). Chima, 292
Dow Chemical Company (1965). Industrial Bio-Test Laboratories, Unpublished Report, Acute vapor inhalation toxicity of TX-52 3,3,3-trifluoropropene (September 22) ; cited in TSCA 8E submission 8EHQ-1291-1918; Fiche Number OTS0535015).
Lu G et al. (1953). Anesthesia XLI: The anesthetic roperties of certain fluorinated hydrocarbons and ethers. Anesthesiology, 14:466-472.
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