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Diss Factsheets
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EC number: 930-936-3 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Description of key information
Repeated Dose Oral 90d-NOAEL=500ppm (~34 mg/kg/day) for rats (equivalent or similar to OECD TG 408)
Repeated Dose Dermal 90d NAOEL-125 mg/kg/day for rats (equivalent or similar to OECD TG 411)
Repeated Dose Inhalation 90d-Testing not required based on Column 2 Annex IX.
Key value for chemical safety assessment
- Toxic effect type:
- dose-dependent
Additional information
Dermal: The study substance is expected to have a low order of repeated dose toxicity by the dermal route of exposure. Testing was performed in a manner similar or equivalent to currently established OECD guidelines. Following 90 days of dermal exposure, the NOAEL for rats was determined to be 125 mg/kg/day. Statistically significant changes in serum chemistry parameters for males and females and changes in relative kidney weights in males were observed at the next highest dose of 500mg/kg/day. However, these limited effects are not indicative of significant toxicity and occur at doses above the guidance values for classification.
Oral: The study substance is expected to have a low order of repeated dose toxicity by the oral route of exposure. Testing was performed in a manner similar or equivalent to currently established OECD guidelines. Following 90d of oral exposure, the NOAEL for rats was determined to be 500ppm (34.6-38.4 mg/kg bw/day). Effects on organ weights were observed at the next highest dose of 5000ppm (340-380 mg/kg/day) and were limited to increases in the absolute and/or relative weight of the kidney (both sexes) and of the adrenals and liver (females). However, there was no evidence of organ dysfunction (including no abnormal histopathology) at any dose. Overall, the limited effects observed were not indicative of significant toxicity and occurred at doses above the guidance values for classification.
Inhalation: In accordance with Column 2 of REACH Annex IX, repeated dose toxicity testing via the inhalation route is not necessary for the study substance as this exposure route is not the most appropriate route of administration, having regard to the likely route of human exposure.
Justification for classification or non-classification
The limited effects observed following oral and dermal administration of the study substance were not indicative of significant toxicity and occurred at doses above the guidance values for classification. Therefore, these findings do not warrant classification of the study substance for target organ toxicity (repeated exposure) under the new Regulation (EC) 1272/2008 on classification, labeling, and packaging of substances and mixtures (CLP), under the Directive 67/518/EEC for dangerous substances and Directive 1999/45/EC for preparations, or under the Globally Harmonized System of Classification and Labelling of Chemicals (GHS).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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