Registration Dossier
Registration Dossier
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EC number: 690-680-0 | CAS number: 19358-05-5
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2013
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- GLP compliance:
- yes
- Test type:
- acute toxic class method
Test material
- Reference substance name:
- 2,2-dimethyl-4-methylidene-1,3-dioxolane
- EC Number:
- 690-680-0
- Cas Number:
- 19358-05-5
- Molecular formula:
- C6H10O2
- IUPAC Name:
- 2,2-dimethyl-4-methylidene-1,3-dioxolane
Constituent 1
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mL/kg bw
- Based on:
- test mat.
- Mortality:
- The test item did not cause mortality at a dose level of 2000 mg/kg bw.
- Clinical signs:
- other: Clinical signs were observed in animals treated at 2000 mg/kg bw with the test item. These included decreased activity (3/6) and hunched back (1/6). The animals became symptom-free at the 6 hours observation after dosing until the end of the observation p
- Gross pathology:
- There was no evidence of the macroscopic observations in animals dosed at 2000 mg/kg bw and terminated on Day 14.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The study result triggers the following classification/labelling:
- EU directive 1999/45/EC: none
- Regulation (EC) No 1272/2008 (CLP): none
- GHS (rev. 4) 2011: CAT. 5 - Executive summary:
Under the conditions of this study, the acute oral LD50 value of the test item BCS-CL73507-BCS-BS22576 (MYDO) was found to be above 2000 mg/kg bw in female CRL:(WI) rats.
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