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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Short-term toxicity to fish

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
short-term toxicity to fish
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1981
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Qualifier:
according to guideline
Guideline:
other: Method A-11
Deviations:
no
GLP compliance:
no
Analytical monitoring:
no
Details on sampling:
Not available
Vehicle:
not specified
Test organisms (species):
Danio rerio (previous name: Brachydanio rerio)
Details on test organisms:
TEST ORGANISM
- Common name: Zebra fish
Test type:
not specified
Water media type:
not specified
Limit test:
no
Total exposure duration:
96 h
Post exposure observation period:
No data
Hardness:
No data
Test temperature:
No data
pH:
7.8 - 8.2
Dissolved oxygen:
No data
Salinity:
No data
Nominal and measured concentrations:
300 and 1000 mg/l
Details on test conditions:
pH: 7.8 - 8.2
Dissolved oxygen: 7 - 7.2 mg/l
Reference substance (positive control):
no
Duration:
48 h
Dose descriptor:
other: TL0
Effect conc.:
> 1 000 mg/L
Nominal / measured:
not specified
Conc. based on:
test mat.
Basis for effect:
mortality (fish)
Duration:
48 h
Dose descriptor:
other: TL50
Effect conc.:
> 1 000 mg/L
Nominal / measured:
not specified
Conc. based on:
test mat.
Basis for effect:
mortality (fish)
Duration:
48 h
Dose descriptor:
other: TL100
Effect conc.:
> 1 000 mg/L
Nominal / measured:
not specified
Conc. based on:
test mat.
Basis for effect:
mortality (fish)
Duration:
96 h
Dose descriptor:
other: TL0
Effect conc.:
> 1 000 mg/L
Nominal / measured:
not specified
Conc. based on:
test mat.
Basis for effect:
mortality (fish)
Duration:
96 h
Dose descriptor:
other: TL50
Effect conc.:
> 1 000 mg/L
Nominal / measured:
not specified
Conc. based on:
test mat.
Basis for effect:
mortality (fish)
Duration:
96 h
Dose descriptor:
other: TL100
Effect conc.:
> 1 000 mg/L
Nominal / measured:
not specified
Conc. based on:
test mat.
Basis for effect:
mortality (fish)
Details on results:
No mortality observed at both the tested concentrations 300 and 1000 mg/l.
Results with reference substance (positive control):
No data
Reported statistics and error estimates:
No data
Validity criteria fulfilled:
not specified
Conclusions:
The study concludes that the loading for lethal concentration (TL50) after 48 hours and 96 hours would be >1000 mg/l based on this being the maximum dosage applied and no mortalities observed.
Executive summary:

Zebra fish were exposed to test substance FAT 20043/C at concentrations 300 and 1000 mg/l for 96 h following an internal method. The study was carried out before the publication of OECD guidelines, however it is deemed to be acceptable for classification determination and is said to be equivalent to OECD Guideline 203. No mortality observed at both the tested concentrations 300 and 1000 mg/l after 96 h. The results are as follows:

TL0 (48 h and 96 h): >1000 mg/l

TL50 (48 hand 96 h) : >1000 mg/l

TL100 (48 h and 96 h) : >1000 mg/l

The study concludes that the loading for lethal concentration (TL50) after 48 hours and 96 hours would be >1000 mg/l based on this being the maximum dosage applied and no mortalities observed.

Description of key information

Zebra fish were exposed to test substance FAT 20043/C at concentrations 300 and 1000 mg/l for 96 h following an internal method. The study was carried out before the publication of OECD guidelines, however it is deemed to be acceptable for classification determination and is said to be equivalent to OECD Guideline 203.

The study was carried out on 20 fishes at two concentration levels (300mg/l and 1000mg/l, 10 fish per concentration). Survivors were counted after 4, 24, 48 and 96 hours. The pH and oxygen levels of the water were also recorded for each tank.

No mortality observed at both the tested concentrations 300 and 1000 mg/l after 96 h.

The study concludes that the loading for lethal concentration (TL50) after 48 hours and 96 hours would be >1000mg/l based on this being the maximum dosage applied and no mortalities observed.

Key value for chemical safety assessment

Fresh water fish

Fresh water fish
Effect concentration:
1 000 mg/L

Additional information

Zebra fish were exposed to test substance FAT 20043/C at concentrations 300 and 1000 mg/l for 96 h following an internal method. The study was carried out before the publication of OECD guidelines, however it is deemed to be acceptable for classification determination and is said to be equivalent to OECD Guideline 203.

The study was carried out on 20 fishes at two concentration levels (300mg/l and 1000mg/l, 10 fish per concentration). Survivors were counted after 4, 24, 48 and 96 hours. The pH and oxygen levels of the water were also recorded for each tank.

No mortality observed at both the tested concentrations 300 and 1000 mg/l after 96 h.

The study concludes that the loading for lethal concentration (TL50) after 48 hours and 96 hours would be >1000mg/l based on this being the maximum dosage applied and no mortalities observed.