p-methoxybenzyl acetate

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2000-03-30 to 2000-05-08

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

comparable to guideline study with acceptable restrictions

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Deviations:

no

Qualifier:

equivalent or similar to guideline

Guideline:

EU Method A.6 (Water Solubility)

Deviations:

no

Qualifier:

according to guideline

Guideline:

other: DIN 38409-3: German standard methods for the examination of water, waste water and sludge; general measures of effects and substances (group H); determination of total organic carbon (TOC) (H 3)

Deviations:

no

Principles of method if other than guideline:

The test substance was stirred in demineralised water. After 24 and 72 h the concentration was analysed through dissolved organic carbon meassurement.

GLP compliance:

no

Type of method:

flask method

Key result

Water solubility:

616 mg/L

Conc. based on:

test mat. (dissolved fraction)

Incubation duration:

>= 24 - <= 72 h

Temp.:

20 °C

Remarks on result:

other: pH value not determined

Water solubility:

627 mg/L

Conc. based on:

test mat. (dissolved fraction)

Incubation duration:

24 h

Temp.:

20 °C

Remarks on result:

other: pH value not determined

Water solubility:

605 mg/L

Conc. based on:

test mat. (dissolved fraction)

Incubation duration:

72 h

Temp.:

20 °C

Remarks on result:

other: pH value not determined

Details on results:

The concentration measured did not differ for more than 15 % and temperatures were kept constant within ± 2 °C. Thus, all validity criteria were fulfilled.

		24 h		72 h
Test item [mg/L]	Content of carbon [mg/L](1)	DOC [mg/L]	Test item [mg/L]	DOC [mg/L]	Test item [mg/L]
1000	665	417.64	627	402.56	605
Solubility of test item [mg/L] (Mean value)		616

DOC-values of test item were corrected by values of control.

(1)= Content of carbon takes into account the purity of test item

Conclusions:

The water solubility of the test substance was determined to be 616 mg/L at 20 °C.

Executive summary:

A study was conducted similar to OECD Guideline 105 for Testing of Chemicals (1995) and Council Regulation (EC) No. 440/2008, Method A.6 to determine the water solubility of the test item. The test was conducted at 20 °C ± 2 °C. The test mixture replicates were stirred at about 600 rpm for 24 and 72 h, respectively. After 24 and 72 h one replicate containing test item and one control replicate were filtered through 0.45 µm and analysed (TOC-analysis). The solubility of the test item was determined as mean of the 24 -72 h time points to be 616 mg/L at 20 ± 2 °C.

Description of key information

The water solubility of the test substance was determined to be 616 mg/L at 20 °C.

Key value for chemical safety assessment

Water solubility:

616 mg/L

at the temperature of:

20 °C

Additional information

A study was conducted similar to OECD Guideline 105 for Testing of Chemicals (1995) and Council Regulation (EC) No. 440/2008, Method A.6 to determine the water solubility of the test item. The test was conducted at 20 °C ± 2 °C. The test mixture replicates were stirred at about 600 rpm for 24 and 72 h, respectively. After 24 and 72 h one replicate containing test item and one control replicate were filtered through 0.45 µm and analysed (TOC-analysis). The solubility of the test item was determined as mean of the 24 -72 h time points to be 616 mg/L at 20 ± 2 °C.